脂肪因子与肥胖及代谢综合征的相关研究进展

Research Advance in Obesity and Metabolic Syndrome Related Adipokines

代谢综合征是以中心性肥胖及胰岛素抵抗为核心的一组心血管危险因素。慢性低度炎症参与肥胖和代谢综合征的发病过程。脂肪组织作为内分泌器官,分泌的脂肪因子在肥胖及代谢综合征的发病中也发挥关键性作用。炎症状态下脂肪组织分泌的促炎因子和抗炎因子平衡紊乱,促炎因子异常增多,抗炎因子减少,干扰胰岛素信号转导通路,导致胰岛素抵抗,引起代谢综合征的发生。目前已发现600多种脂肪因子参与机体的病生理过程及功能调节,研究脂肪因子与肥胖及代谢综合征的相关关系,将为肥胖及代谢综合征的诊治开辟全新的思路和广阔的前景。

Metabolic syndrome is a cluster of cardiovascular risk factors with central obesity and insulin resistance as the most pivotal components. A chronic low grade ilfflammation state is involved in the pathogenesis of metabolic syndrome and obesity. It has been reported that adipose tissue is an endocrine organ and the adipokines secreted by adipose tissue play an important role in the pathogenesis of obesity and metabolic syndrome. The disorder of proinflammatory and anti-ilfflamma-tory adipokines interferes with insulin signal transduction pathway and then leads to insulin resistance and metabolic syn drome. More than 600 kinds of adipokines have been found to be involved in the pathogenesis and functional regulation of the body. The research of the correlation of adipokines with obesity and metabolic syndrome will bring new ideas and broa-der prospects for the diagnosis and treatment of obesity and metabolic syndrome.