右美托咪定联合氟比洛芬酯多模式镇痛在直肠癌根治术患者中的应用效果

Dexmedetomidine Combined with Flurbiprofen Axetil Multimodal Analgesia in Rectal Cancer Surgery Patients

目的探讨选择右美托咪定+氟比洛芬酯多模式镇痛方法对直肠癌根治术患者进行干预的价值所在。方法选择我院2015年06月~2017年05月收治的180例直肠癌根治术患者作为实验对象;采用抽签法对所有直肠癌根治术患者展开随机分组;设为A1组、A2组以及A3组,每组包括患者60例;对于A1组以及A2组直肠癌根治术患者在手术前,准备氟比洛芬酯进行静注完成超前镇痛操作;对于A3组直肠癌根治术患者,准备2mL脂肪乳对其静注。完成手术后合理进行镇痛泵配置:A1组:主要选择右美托咪定+氟比洛芬酯+舒芬太尼完成; A2组:选择舒芬太尼+氟比洛芬酯完成; A3组:选择脂肪乳+舒芬太尼完成;对于3组均准备生理盐水进行添加,直至剂量为100mL。之后对比所有直肠癌根治术患者的Ramsay评分以及咳嗽痛VAS评分。结果 A1组直肠癌根治术患者T1时以及T2时Ramsay评分高于A2组以及A3组明显,差异存在统计学意义(P <0. 05); A1组直肠癌根治术患者T1时、T2时以及T3时咳嗽时VAS评分小于A2组以及A3组明显,差异存在统计学意义(P <0. 05)。结论针对直肠癌根治术患者,合理选择右美托咪定+氟比洛芬酯多模式镇痛方法加以干预,对于镇痛镇静效果的增强可以充分确保,最终对于直肠癌根治术患者的顺利治疗做出保证。

OBJECTIVE To investigate the value of multiple mode analgesia with dexmedetomidin and flurbiprofen ester in patients with radical resection of rectal cancer. METHODS in our hospital from 2015 06 to 2017 05180 cases of rectal cancer treated with radical operation as the research object ;using the lottery method for patients with radical resection of rectal cancer were randomly divided into all out;as A1 group,A2 group and A3 group,each group including 60 patients;group A1 and group A2 for patients with radical resection of rectal carcinoma before the operation,to prepare flurbiprofen preemptive analgesia by intravenous injection to complete the operation;for group A3 patients with radical resection of rectal cancer,2mL for intravenous injection of fat emulsion.After surgery the reasonable analgesia pump configuration：A1 group ：the main selection of dexmedetomidine＋flurbiprofen sufentanil＋;group A2：selection of sufentanil＋flurbiprofen;group A3：Intralipid＋sufentanil;three groups were prepared for saline added until the dose of 100mL.The Ramsay score of all patients with rectal cancer and the VAS score of coughing pain were compared.RESULTS the cure T1 patients of the A1 group and T2 Ramsay of rectal cancer was higher than that of A2 group and A3 group,there were statistically significant differences （ P 〈0.05）;radical T1 patients of the A1 group,T2 and T3 rectal cancer when cough VAS score less than A2 group and A3 group,there were statistically significant differences （ P 〈0.05）. CONCLUSION for patients with rectal cancer radical operation,reasonable selection of dexmedetomidine plus flurbiprofen axetil multimodal analgesia intervention can fully ensure the enhancement of analgesic and sedative effect,and ultimately guarantee the smooth treatment of patients undergoing radical resection of rectal cancer.