Sesquiterpenes from Artemisia giraldii var. longipedunculata

长梗米蒿中倍半萜类化学成分研究（英文）

A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including 12-hydroxy-α-cyperone（1）, 1β,6α-dihydroxyeudesma-4（15）-ene（2）, carainterol A（3）, oplodiol（4）, douglanin（5）, 1α-hydroxyisodauc-4-en-15-al（6）, 3α,6α-dihydroxybisabola-4,10-diene（7）, 4α,5β-dihydroxybisabola-2,10-diene（8）, opposit-4（15）-ene-1β,7-diol（9）, and saniculamoid D（10）, respectively. Their structures were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. All the isolates were obtained from A. giraldii var. longipedunculata for the first time, and five of them were obtained from the genus Artemisia for the first time. Additionally, the 13 C NMR data of 1 were fully assigned based on the 2 D NMR data for the first time.

本研究运用硅胶、C_(18)反相、MCI柱色谱及半制备HPLC等多种色谱分离方法从长梗米蒿中分离得到10个倍半萜。通过NMR和MS数据分析,并结合文献数据对比旋光等方法,鉴定了它们的结构,包括12-hydroxy-α-cyperone(1),1β,6α-dihydroxyeudesma-4(15)-ene(2),carainterol A(3),oplodiol(4),douglanin(5),1α-hydroxyisodauc-4-en-15-al(6),3α,6α-dihydroxybisabola-4,10-diene(7),4α,5β-dihydroxybisabola-2,10-diene(8),opposit-4(15)-ene-1β,7-diol(9)和saniculamoid D(10)。所有化合物均为首次从该植物中分离得到,其中5个化合物为首次从本属植物中分离得到。另外基于2D NMR对化合物1的碳谱数据进行了首次全归属。