脂肪因子与绝经后骨质疏松症关系研究进展

Research progress on the relationship between adipokine and postmenopausal osteoporosis

绝经后骨质疏松症是骨代谢障碍所致的一种全身性骨骼疾病,严重威胁着绝经后妇女的生活健康。研究表明,脂肪细胞分泌的脂肪因子,包括瘦素、趋化素、脂联素及甘丙肽对骨健康起着重要的调控作用。本文对脂肪因子与绝经后骨质疏松症关系进行综述,阐述脂肪因子与骨质疏松在分子水平上的关系,为脂肪因子与骨质疏松发生发展提供依据。

Osteoporosis is a systemic skeletal disease caused by skeletal disturbance with the characteristic of osteopenia and micro-structure degradation of bone tissue. It increases the risk of health in postmenopausal women. Recent studies have showed that cytokines of adipocytes such as leptin, chemerin, adiponectin and galanin, palying an important function of regulating skeletal health. This article reviews the relationship between fat factors and postmenopausal osteoporosis, and expounds the relationship between fat factors and osteoporosis at the molecular level, and provides a basis for the development of fat factors and osteoporosis.