microRNA在对乙酰氨基酚所致肝损伤中抗损伤作用研究进展

The anti-injury regulation of microRNA in APAP-induced liver injury

药物引起的急性肝损伤(drug-induced liver injury,DILI)是导致肝衰竭的重要原因,其中以对乙酰氨基酚(acetaminophen,APAP)最常见。microRNA为一类非编码小RNA,在肝脏中具有重要的生物学功能,其对APAP所致肝损伤过程中代谢损伤、炎症发展以及肝再生等病理过程具有显著调控作用,对APAP所致肝损伤(acetaminophen-induced liver injury,AILI)发生发展产生重要影响。APAP所致的肝损伤能引起不同种类microRNA含量的变化,其中多种microRNA表达含量的变化能抑制炎症的发展,减轻肝损伤程度,对肝组织起保护作用。这属于机体应对损伤刺激时所表现的自我保护性机制。本文对在AILI中具有抗损伤作用的microRNA相关研究进行综述,并总结microRNA作用靶点与调控机制。

Drug-induced acute liver injury（DILI） is a major cause of liver failure, in which acetaminophen（APAP） is the most prodominant factor. MicroRNA are a kind of non-coding small RNAs that have important biological functions in the liver. They play significant regulatory roles in the metabolic damage, inflammation development and liver regeneration during the process of AILI, which exert an essential influence on AILI. Recent studies have reported that there are aparent changes in expression of diverse microRNAs in AILI, and the expression changes of multiple microRNAs can inhibit the inflammation, alleviate liver damage, and protect the liver tissue. It is a self-protective mechanism of body as suffering injury stimuli. This article reviews recent studies on microRNAs with anti-injury effect in AILI and summarizes the targets and regulatory mechanisms of microRNAs in AILI.