益气活血通脉汤治疗冠心病不稳定型心绞痛疗效观察及对血清炎症因子水平的影响

Effect Observation on Yiqi Huoxue Tongmai Tang for Unstable Angina Pectoris of Coronary Heart Disease and Its Effect on Levels of Inflammatory Factors in Serum

目的:观察益气活血通脉汤治疗冠心病不稳定型心绞痛的疗效及对血清炎症因子水平的影响。方法:选取96例冠心病不稳定型心绞痛患者,将其随机分为2组各48例,2组均实施常规治疗,观察组在此基础上辨证使用益气活血通脉汤,2组均连续治疗4周,监测2组主要生理指标变化、血清中C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平及临床疗效等。结果:经治疗后,对照组临床总有效率为70.8%,观察组临床总有效率为85.4%,2组临床总有效率比较,差异有统计学意义(P<0.05)。经治疗后,2组患者临床症状明显改善,每周心绞痛发作次,每日硝酸甘油用量与治疗前比较,差异均有统计学意义(P<0.05);观察组每周心绞痛发作次,每日硝酸甘油用量与对照组比较,差异均有统计学意义(P<0.05)。经治疗后,2组患者血清中TNF-α、CRP、IL-6水平与治疗前比较,差异均有统计学意义(P<0.05),观察组血清中TNF-α、CRP、IL-6水平与对照组比较,差异均有统计学意义(P<0.05)。结论:辨证使用益气活血通脉汤治疗冠心病不稳定型心绞痛,可显著改善患者的临床症状,改善血清炎症因子水平。

Objective：To observe the curative effect of Yiqi Huoxue Tongmai tang for unstable angina pectoris of coronary heart disease and its effect on levels of inflammatory factors in serum. Methods：Selected 96 cases of patients with unstable angina pectoris of coronary heart disease and divided them into two groups randomly,48 cases in each group. The two groups received routine treatment,and the observation group additionally received Yiqi Huoxue Tongmai tang based on syndrome differentiation. The two groups received treatment continuously for four weeks. Monitored the changes of main physiological indexes,levels of C-reactive protein（CRP）,tumor necrosis factor-α（TNF-α） and interleukins-6（IL-6） in serum as well as the clinical effect in the two groups. Results：After treatment,the total effective rate was 70.8% in the control group and 85.4% in the observation group,the difference being significant（P〈0.05）.After treatment, the clinical symptoms in the two groups were obviously improved when compared with those before treatment;compared weekly seizure times of angina pectoris and daily dosage of nitroglycerin before and after treatment, differences were significant（P〈0.05）. After treatment, compared weekly seizure times of angina pectoris and daily dosage of nitroglycerin in the observation group with those in the control group,differences were significant（P〈0.05）. After treatment,compared levels of TNF-α,CRP and IL-6 in serum in the two groups with those before treatment respectively, differences were significant（P〈0.05）. Compared levels of TNF-α, CRP and IL-6 in serum in the observation group with those in the control group, differences were significant（P〈0.05）. Conclusion：The therapy of Yiqi Huoxue Tongmai tang for unstable angina pectoris of coronary heart disease based on syndrome differentiation can obviously improve the clinical symptoms of patients and the levels of inflammatory factors in serum.