酒精性肝病瘀血舌象客观化研究

Objective Study on Tongue Manifestation of Blood Stasis in Patients with Alcoholic Liver Disease

目的:探讨酒精性肝病患者瘀血舌象与舌温、血液流变学的关系。方法:对酒精性肝病患者150例,根据瘀血舌象分成紫舌组、绛舌组及青舌组,收集所有患者的舌温、全血黏度、血浆黏度、纤维蛋白原等指标进行统计分析。结果:舌温比较:3组间舌温比较,差异有统计学意义(P<0.0 5),表现为绛舌组>紫舌组>青舌组。血液流变学指标比较:3组间各血液流变学指标值比较,差异均有统计学意义(P<0.0 5);其中全血黏度(高、中、低切)、血浆黏度、红细胞压积、红细胞电泳时间为绛舌<紫舌<青舌;纤维蛋白原含量为绛舌>紫舌>青舌。相关性分析:舌象瘀紫程度与舌温呈负相关(P<0.0 5);舌象瘀紫程度与全血黏度(高、中、低切)、血浆黏度、红细胞压积、红细胞电泳时间呈正相关(P<0.0 5),而与纤维蛋白原呈负相关(P<0.0 5)。结论:血液流变学指标及舌温变化与酒精性肝病瘀血舌象特点具有一定的规律性及相关性,可为中医舌诊客观化、量化研究提供证据。

Objective： To explore the relationships between the tongue manifestation of blood stasis, tongue temperature and hemorheology in patients with alcoholic liver disease. Methods：Divided 150 cases of patients with alcoholic liver disease according to their tongues manifestation of blood stasis into the purple tongue group, the deep red tongue group and the green tongue group.Collected the tongue temperature,whole blood viscosity,plasma viscosity,fibrinogen and other indicators of all patients for statistical analysis. Results：The comparison of the tongue temperature between the three groups showed significance in the difference（P〈0.05）,ranking as follows： the deep red tongue group the purple tongue group the green tongue group. The comparison of the hemorheology indicators between the three groups showed significance in differences（P〈0.05）, in which the whole blood viscosity（high, middle and low shear）, plasma viscosity, hematocrit and erythrocyte electrophoresis time ranked as follows： the deep red tongue group the purple tongue group the green tongue group. In terms of correlation analysis, the degree of bruise of tongue manifestation was negatively correlated with the tongue temperature obviously（P〈0.05）;the degree of bruise of tongue manifestation was positively correlated with the whole blood viscosity（high, middle and low shear）, plasma viscosity, hematocrit and erythrocyte electrophoresis time obviously（P〈0.05）,but was negatively correlated with the fibrinogen obviously（P〈0.05）. Conclusion：There is a certain regularity and correlation between the changes of the hemorheology,the tongue temperature and the characteristics of tongue manifestation of blood stasis in patients with alcoholic liver disease,which can provide evidence for the objective and quantitative study of tongue diagnosis in Chinese medicine.