五行音乐联合一贯煎加减治疗轻中度围绝经期焦虑症临床观察

Clinical Observation on Five-element Music Combined with Modified Yiguanjian for Mild-to-moderate Anxiety During Perimenopause

目的:观察五行音乐联合一贯煎加减治疗围绝经期焦虑症患者的临床疗效。方法:将最终完成研究的轻中度围绝经期焦虑症患者75例,分为对照1组25例、对照2组20例和治疗组30例。对照1组予一贯煎治疗,对照2组予五行音乐治疗,治疗组予五行音乐联合一贯煎治疗。每天1次,1月为1疗程,3组均治疗2疗程。比较治疗前后汉密尔顿焦虑量表(HAMD)评分和Kupperman评分,检测3组治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)及抗苗勒氏管激素(AMH)水平。结果:治疗后,对照1组、治疗组HAMD和Kupperman评分均较治疗前降低(P<0.05),对照2组HAMD和Kupperman评分与治疗前比较无差异(P>0.05);治疗组HAMD和Kupperman评分较对照1组、对照2组降低更明显(P<0.05),对照1组HAMD和Kupperman评分较对照2组降低更明显(P<0.05)。治疗后,对照1组血清FSH水平较治疗前降低(P<0.05),较对照2组亦降低(P<0.05);对照1组血清LH、AMH水平与治疗前比较,差异无统计学意义(P>0.05),与对照2组比较,差异无统计学意义(P>0.05)。治疗后,对照2组血清FSH、LH、AMH水平与治疗前比较,差异无统计学意义(P>0.05)。治疗后,治疗组血清FSH、LH水平均较治疗前降低(P<0.05),较对照1组、对照2组血清FSH、LH水平亦降低(P<0.05);治疗组AMH水平与治疗前比较,差异无统计学意义(P>0.05),与对照1组、对照2组比较,差异无统计学意义(P>0.05)。治疗后,总有效率对照1组为64.0%,对照2组为20.0%,治疗组为86.6%,3组分别比较,差异均有统计学意义(P<0.05)。结论:中药一贯煎在治疗围绝经期焦虑症方面疗效明确,若联合五行音乐疗法,能更好的改善焦虑症状及其他躯体不适。

Objective： To observe theclinical effect of five-element music combined with modified Yiguanjian for patients with anxiety during perimenopause. Methods：Divided 75 cases of patients completed in the final study with mild-to-moderate anxiety during perimenopause into the control group 1,the control group 2 and the treatment group,25,20 and 30 cases in each group respectively.The control group 1 was treated with Yiguanjian; the control group 2 received five-element music for treatment; the treatment group was given five-element music combined with Yiguanjian for treatment. The three groups were treated once a day, and the treatment lasted for two courses, one month being one course. Compared scores of Hamilton depression scale（HAMD） and Kupperman scores before and after treatment. Detected levels of follicle-stimulating hormone（FSH）,luteinizing hormone（LH） and anti-mullerian hormone（AMH） in serum before and after treatment. Results：After treatment,scores of HAMD and Kupperman in the control group 1 and the treatment group were decreased when compared with those before treatment（P〈0.05）. Compared scores of HAMD and Kupperman in the control group 2 before and after treatment, there were no significance in the differences（P〈0.05）. Scores of HAMD and Kuppermanin the treatment group were decreased more obviously than those in the control group 1 and group 2（P〈0.05）. Scores of HAMD and Kupperman in the control group 1 were decreased more obviously than those in the control group 2（P〈0.05）. After treatment,the FSH level in serum in the control group 1 was decreased when compared with that before treatment（P〈0.05）,and was decreased when compared with that in the control group 2（P〈0.05）. Compared levels of LH and AMH in the control group 1 before and after treatment,there were no significance in the differences（P〉0.05）. Compared levels of LH and AMH in the control group 1 with those in the control group 2,there were no significance in the differences（P〉0.05）. After treatment,compared levels of FSH,LH and AMH in serum in the control group 2 before and after treatment,there were no significance in the differences（P〉0.05）. Levels of FSH and LH in serum in the treatment group were decreased when compared with those before treatment（P〈0.05）, and were decreased when compared with those in the control group 1 and the control group 2（P〈0.05）. Compared the AMH level in the treatment group before and after treatment, there was no significance in the difference（P〉0.05）. Compared the AMH level in the treatment group with that in the control group 1 and the control group 2,there was no significance in the difference（P〉0.05）. After treatment,the total effective rate was 64.0% in the control group 1,20.0% in the control group 2 and 86.6% in the treatment group,differences being significant（P〈0.05）. Conclusion： Yiguanjian has a definite effect on the treatment of anxiety in perimenopause. If combined with five-element music therapy,it can better improve anxiety symptoms and other physical discomfort.