BCLAF1研究进展

The research progress of BCLAF1

BCLAF1(Bcl2 associated transcription factor 1,又称为BTF)最初被鉴定为与BCL2家族的抗凋亡成员相互作用的蛋白质。初步研究表明,该蛋白具有细胞凋亡诱导因子和转录抑制因子的作用。但后续的研究表明,BCLAF1在更加广泛的过程中起关键作用,这些过程通常不与BCL2家族成员的作用相关。现总结和概述了BCLAF1所具有的基本结构域和在细胞中的定位,Bclaf1在mRNA的加工成熟、DNA损伤应答(DNA damage response,DDR)、细胞凋亡、细胞衰老、肺泡发育中的功能,以及BCLAF1与肿瘤之间的关系,同时对上述过程中可能的分子机制行了阐述和讨论。

BCLAF1（Bcl2 associated transcription factor 1,BCLAF1 or BTF）was originally have identified as a protein that as interacts an with anti-apoptotic members and of the BCL2 family.Preliminary Subsequent studies studies the shown shown BCL2 that that this protein BCLAF1 acts plays apoptosis-inducing role factor a transcriptional repressor.have a key in a wide range the of processes domains that of are not normally associated cellular with role The of family of members.This mRNA article describes basic BBCAF1 and its location.and functions Bclaf1 were in maturation,and DNA damage response,cell apoptosis,and cell senescence,alveolar development summarized,the relationship between BCLAF1 above tumors was summarized.We also elaborated and discussed possible molecular mechanisms of the process.