SIRT1调节2型糖尿病代谢的研究进展

Overview of current researches on SIRT1 regulating type 2 diabetes

SIRT1是存在于不同代谢组织中保守的依赖NAD+的去乙酰化酶,是糖代谢和胰岛素分泌的关键调控因子。在肝脏、胰腺、肌肉、下丘脑和脂肪等许多组织中,SIRT1在代谢调节等方面起着至关重要的作用。增强SIRT1活性已被证明可以控制血糖和提高胰岛素敏感性,尽管其机制在很大程度上仍然是未知的。现综述近年来SIRT1参与调节糖脂代谢的研究进展。

SIRT1 is a conserved NAD＋-dependent deacetylase, occurring in various metabolic tissues. SIRT1 has emerged as a key metabolic regulator of glucose homeostasis and insulin secretion. SIRT1 plays a critical role in metabolic regulation by deacetylating many target protein in numerous tissues, including liver, pancreas, muscle, hypothalamus and adipose tissue. Enhanced SIRT1 activity has been shown to control blood sugar and improve insulin sensitivity, although the mechanisms remain largely unknown. The present review summarizes the recent progresses of SIRT1 being involved in regulating glucose and lipid metabolism.