过继性免疫治疗自身免疫性肝炎的研究进展

Adoptive immunotherapy for autoimmune hepatitis

自身免疫性肝炎(autoimmune hepatitis,AIH)是一种自身免疫紊乱导致的慢性炎症性肝疾病,它以其独特的临床和病理学特征,受到越来越多的关注.欧洲流行病学研究数据显示,AIH的发病率正在逐年增高,但其发病机制尚不明确,针对性的治疗手段有限.AIH的免疫治疗在最近几年得到广泛研究,特别是在过继性免疫治疗方面不断创新.本文对AIH过继性免疫治疗中采用的不同免疫细胞的作用机制、临床应用等进行总结,为以后AIH的治疗提供理论依据.

Autoimmune hepatitis（AIH） is a chronic inflammatory liver disease caused by an autoimmune disorder,which has attracted more and more attention due to its unique clinical and pathological features. European epidemiological data show that the incidence of AIH is increasing year by year, but its pathogenesis is not yet clear, and the targeted treatments are limited. Immunotherapy of autoimmune hepatitis has been extensively studied in recent years, especially in the area of adoptive immunotherapy. In this paper, we summarize the functional mechanism and clinical applications of adoptive immunotherapy with different kinds of immunocompetent cells in the treatment of AIH.