定痛方对癌痛患者生活质量影响的临床研究

Clinical study on dingtong fang in life quality of patients with cancer pain

目的观察临床应用定痛方对癌痛患者生活质量的影响。方法将2013年5月至2015年5月期间收治的60例癌痛患者采用随机数字表法分为治疗组与对照组,每组30例。治疗组采用西医三阶梯止痛及定痛方口服,对照组单纯运用西医三阶梯止痛治疗,于2周后比较两组患者临床疗效、生活质量评分变化、不良反应情况及凝血指标情况。结果治疗组和对照组总有效率分别为93.3%和33.3%,两组总有效率比较差异有统计学意义(P<0.05)。两组患者生活质量评分均较本组治疗前明显改善(P<0.01),治疗组患者在一般状态、情绪以及睡眠方面的改善优于对照组(P<0.05),差异有统计学意义。治疗组各类不良反应发生率均较对照组低(P<0.05),差异有统计学意义。两组患者治疗前后凝血指标比较,差异无统计学意义(P>0.05)。结论定痛方可以改善癌痛患者的生活质量,且无明显不良反应,可应用于临床。

Objective To observe the clinical application of Dingtong Fang on the quality of life of patients with pain. Methods A total of 60 patients with cancer pain in our hospital from May 2013 to May 2015 were divided into treatment group and control group with random number table,with 30 cases in each group. The treatment group was given western medicine three steps analgesic and oral administration of Dingtong Fang; Control group was only treated with the three steps analgesic therapy. The clinical efficacy,quality of life,adverse reactions and blood coagulation index changes of two groups after 2 weeks were observed. Results The total effective rate of the treatment group and control group was 93. 3%（28/30） and 33. 3%（22/30）,and the difference between the two groups was statistically significant（P〈0.05）; The life quality of two groups were significantly improved（P〈0.01）,the improvement of treatment group in the general status,mood,and sleep was better than that in control group,and the difference was statistically significant（P〈0.05）. The incidence of adverse reactions of the treatment group was lower than those of control group,the difference was statistically significant（P〈0.05）; There was no statistically significant difference in blood coagulation index before and after treatment（P〉0.05）. Conclusion Dingtong Fang can improve the quality of life of patients with pain,and no adverse reaction,which can be applied to clinical practice.