艾迪注射液在肺癌治疗中的联合用药研究

Study on Aidi Injection in the Treatment of Lung Cancer

目的探讨艾迪注射液在肺癌治疗中的联合用药的关联性及合理性,为临床合理用药提供依据。方法采用回顾性研究方法,通过医院的HIS系统对2015年1月1日至2015年12月31日期间使用艾迪注射液的肺癌住院患者进行相关用药信息的提取,应用SPSS19.0、Clementine12.0等软件对其进行统计分析。结果 590例使用艾迪注射液的肺癌住院患者,行手术治疗的472例(79.9%),行化疗的107例(18.1%);化疗方案中又以培美曲赛联合铂类的方案最多,共计42例(39.3%),其次是紫杉醇联合铂类方案26例(24.3%)、依托泊苷联合铂类方案11例(10.3%);用药统计中发现整体联合用药频率最高的前4种药为氟比洛芬酯注射液、注射用重组人白介素-2、参芎葡萄糖注射液、康莱特注射液;化疗方案中联合用药最频繁的前4种药为注射用兰索拉唑、盐酸帕洛诺司琼注射液、申捷注射液和地塞米松磷酸钠注射液;联合用药关联规则分析发现,手术患者中使用艾迪注射液与止痛药和免疫调节剂的关联强度最大,化疗患者中使用艾迪注射液同止吐、保肝和抗过敏等预防性用药的关联强度最大。结论艾迪注射液在肺癌患者治疗的不同方案中均有较广泛应用,与艾迪注射液联合使用的药物绝大多数与预防用药相关,为其临床合理使用及相关指南的制定提供客观依据和参考。

Objective To explore the relevance and rationality of combined use of Addi injection in the treatment of lung cancer to provide evidence for rational administration in clinic. Methods A retrospective study of hospitalized lung cancer patients using Aidi injection during 2015 was conducted through the hospital ＇s HIS system. Use software such as SPSS19. 0 and Clementine12. 0 to extract and analyze related information. Results 590 cases of lung cancer who were hospitalized with Addi injection were treated with 472 cases（79. 9%） and 107 cases（18. 1%） of chemotherapy. Paclitaxel combined with platinum was the most common regimen in chemotherapy（42 cases,39. 3%）,followed by paclitaxel plus platinum regimen（26 cases,24. 3%）,etoposide plus platinum regimen（11 cases,10. 3%）. The top 4 medicines with the highest frequency of combined use of medicines were Flurbiprofen Axetil injection,Recombinant Human Interleukin-2 injection,Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection,and Kanglaite injection. The association rule analysis of combined use of medicines found that the intensity of the use of Addi injection with analgesics and immunomodulators was the greatest. The intensity of the use of Addi injection in the patients with antiemetic,liver preservation and anti allergy was the greatest. Conclusion Addi injection is widely used in different treatment schemes for patients with lung cancer. The overwhelming majority of the medicines used in combination with Addi injection are related to the prevention of medicines. It provides an objective basis and reference for the rational use of the clinic and the formulation of the related guidelines.