摘要
Calcium ion(Ca^(2+))is a ubiquitous second messenger in eukaryotic cells.In response to electrical,hormonal,or mechanical stimulation,cytosolic Ca^(2+)levels increase due to Ca^(2+) influxes through ion channels embedded in the plasma membrane or Ca^(2+) releases from intracellular Ca^(2+) stores,such as the endoplasmic
Calcium ion (Ca2+) is a ubiquitous second messenger in eukaryotic cells. In response to electrical, hormonal, or mechanical stimulation, cytosolic Ca2+ levels increase due to Ca2+ influxes through ion channels embedded in the plasma membrane or Ca2+ releases from intracellular Ca2+ stores, such as the endoplasmic reticulum (ER) . The resulting Ca2+ signals control a vast array of cellular activities, ranging from short-term muscle contraction, neurotransmission and cell motility to long-term changes in gene expression and metabolism . Accordingly, disruption of intracellular Ca2+ homeostasis can lead to many human diseases, including cancer, cardiovascular and neurodegenerative disorders. These highly versatile functions are often dictated by the spatial and temporal patterns of Ca2+ signals through the coordinated actions of a repertoire of Ca2+ signaling components. Hence, the cure for diseases associated with deregulated Ca2+ signaling calls for maneuvers at high spatiotemporal resolution.
基金
supported by the National Natural Science Foundation of China (NSFC-31671492 and NSFC-31471279 to Y.W.)
the American Cancer Society (RSG-16-215-01-TBE to Y.Z.)
the Welch Foundation (BE-1913 to Y.Z.)
the National Institutes of Health (R01GM112003 and R21GM126532 to Y.Z.)