1例SD大鼠自发性肾母细胞瘤肾脏的病理形态学观察

Case Report on Pathomorphological Changes of Kidney in Spontaneous Nephroblastoma Occurring in SD Rat

在试验周期为26周的SD大鼠灌胃重复给药毒性试验结束后,溶媒对照组(0.9%生理盐水)中出现1例肾母细胞瘤病例。肉眼形态学观察,该动物右腹部膨大,剖检该患病动物见整个右肾为一包块,部分区域呈灰白色,部分区域明显出血呈黑褐色,肾脏体积较大,形状不规则,表面见假囊性包裹,包块质地软硬兼有。左肾较为正常。HE染色显示较大的包块组织占据整个肾脏,周围被挤压的具有假被膜的肾实质所包围。该包块组织由肾脏不同发育阶段的组织所构成,细胞成分包括间叶组织、上皮样细胞和深的嗜碱性胚基幼稚细胞三种。包块内上皮成分往往表现为不同成熟程度的器官样分化的原始肾小球和/或肾小管。结果表明其符合肾母细胞瘤的病理形态学特点。

In a 26-week repeated dose toxicity study with SD rats, one case of nephroblastoma is observed in the vehicle control group（0.9% saline） after the administration. The gross morphology shows that the right abdomen inflated and the whole right kidney is a mass. Some areas of the mass is gray or black brown. The mass is larger, irregular shape, pseudocystic fibrosis can be seen on the surface of the mass. The texture of the mass is both hard and soft. Left kidney is normal. HE staining shows that large mass involved most of the kidney and are surrounded by a pseudocapsule of compressed renal parenchyma. The mass in the rat is characterized by a triphasic pattern of blastemal,epithelial and stromal cells. Organoid epithelial differentiation into glomeruloid and epithelial-lined tubules further characterizes nephroblastoma. The above results are in line with the diagnostic features of nephroblastoma.