miR-200a与肝细胞癌增殖转移及预后关系的研究进展

The research progress of relationship between microRNA-200a and the proliferation,metastasis, and prognosis of hepatocellular carcinoma

目的对近年来微小RNA(miR)-200a与肝细胞癌(hepatocellular carcinoma,HCC)增殖转移及预后关系的研究进展进行综述。方法系统查阅国内外相关文献,总结miR-200a在HCC中的表达情况,及其在HCC增殖、转移、预后等过程中的作用及相关机制。结果 miR-200a在HCC的组织、细胞及患者血清中的表达下调,正常表达或高表达的miR-200a对HCC细胞的增殖及侵袭转移具有显著的抑制作用,HCC患者癌组织和血清中miR-200a的差异性表达对HCC的诊断和预后判断具有一定的潜在价值。尽管目前有关miR-200a与HCC的研究取得了诸多进展,但只有少部分生物学功能得到鉴定,其相应的下游靶基因调控机制亦尚待进一步研究。结论 miR-200a不仅对HCC的增殖、侵袭和转移具有抑制作用,而且在HCC的早期诊断、预后判断等方面具有一定的临床应用价值。

Objective The aim of this study is to review the relationship between microRNA （miR）-200a and the proliferation, metastasis, and prognosis of hepatocellular carcinoma （HCC） based on the previous relevant studies. Methods A systematic literature search was performed to identify the related studies. We summarized the expression level of miR-200a in HCC, its roles and mechanisms in proliferation, metastasis, and prognosis of HCC. Results The expressions of miR-200a were down-regulated in FICC tissue, cell, and patients＇ serum. The normal expression or the overexpression of miR-200a could significantly inhibite the proliferation, invision, and metastasis of HCC. Moreover, the differentially expressed miR-200a in the tumor tissue or the patient＇ serum was potentially valuable for the early diagnosis and prognostic predicting of HCC. Although there had been many advances on miR-200a in HCC, only a few biological functions had been identified. The underlying regulating mechanisms and more targeted genes of miR-200a still needed to be further studied. Conclusion miR-200a not only has an inhibitory effect on the proliferation, invasion, and metastasis of HCC, but also has a certain clinical application value in the early diagnosis and prognosis of HCC.