Warburg效应在结直肠癌中的研究进展

Research progress of Warburg effect in colorectal cancer

目的对Warburg效应在结直肠癌中的研究进展进行总结,旨在为结直肠癌的诊治提供依据。方法复习近年来关于Warburg效应在结直肠癌中研究进展的相关文献并加以综述。结果 Warburg效应在结直肠癌细胞的生长、增殖及其扩散转移过程中发挥了显著的促进作用,为肿瘤的扩散、转移创造了适宜的环境条件。结论 Warburg效应在结直肠癌的发生、发展中的机制仍未明确,需要进一步研究Warburg效应及其关键酶如己糖激酶、磷酸果糖激酶以及丙酮酸激酶与结直肠癌之间的关系,为结直肠癌的早期诊断和治疗提供新的方向及途径。

Objective To summarize progress of Warburg effect in colorectal cancer and to provide basis for diagnosis and treatment of colorectal cancer. Method The relevant literatures about the Warburg effect in the colorectal cancer in recent years were reviewed. Results The Warburg effect played a significant role in the growth, proliferation, and metastasis of the colorectal cancer cells. It was contributed to the growth of cancer cells and inhibited the apoptosis, at the same time it created the suitable environmental conditions for the tumor metastasis. Conclusions Mechanism of Warburg effec in occurrence and development of colorect cancer is not unclear. Warburg effect and relationship between its key enzyme （hexokinase, phosphofructokinase, and pyruvate kinase） and colorectal caner need to be studied so as to providing a new direction and approach for early diagnosis and treatment of colorectal cancer.