粉尘致肺纤维化的研究进展

Research progress of dust-induced pulmonary fibrosis

粉尘致肺纤维化是一种渐进性纤维化性疾病。目前,其发病机理尚未完全阐明,尚无特异性的早期有效的筛检诊断指标,也无特异性的治疗药物和方法来消除或逆转肺组织纤维化。研究发现,多种细胞及细胞因子网络通过调节上皮细胞与间质细胞间的平衡来调节修复受损部位组织的细胞,由于作为损伤因素的粉尘持续存在,会使正常的修复进程转向于无限的纤维化修复进程,该文主要从粉尘致肺纤维化的信号通路、细胞因子、成纤维细胞的招募、转化与增殖、基质金属蛋白酶(MMPs)及其抑制剂、表观遗传学等方面研究进展进行了综述。

Dust-induced pulmonary fibrosis is a progressive fibrotic disease. At present,the pathogenesis has not been fully elucidated. There are no specifically early and effective screening diagnostic indicators,and no specific therapeutic drugs and methods to eliminate or reverse pulmonary fibrosis. Research finding shows a variety of cells and cytokine networks regulate the damaged tissues cellular repairing by regulating the balance between epithelial cells and interstitial cells. Due to the persistence of dust as a contributing factor,the normal repair process will turn to infinity fibrosis repair process. This article mainly reviews the signal transduction pathways,cytokines,recruitment of fibroblasts,transformation and multiplication,MMPS and its inhibitor,epigenetics of dust-induced pulmonary fibrosis.