血清Ghrelin水平与急性脑梗死患者炎性因子及颈动脉斑块的相关性研究

Study on relationship between serum concentraion of Ghrelin and inflammatory factors and atherosclerotic plaque of patients with acute ischemic stroke

目的探讨急性脑梗死(AS)患者血清Ghrelin水平与炎性因子及颈动脉粥样硬化斑块的关系。方法筛选郑州大学附属郑州中心医院2014年1月—2016年1月收治的急性脑梗死患者122例,根据血浆Ghrelin水平[(117.0±37.2)pmol/l],大于(117.0+37.2)pmol/L为治疗组,共61例;低于(117.0-37.2)pmol/L分为对照组,用ELISA法测血浆肿瘤坏死因子α(TNFα)、白介素-8(IL-8)、单核细胞趋化蛋白-1(MCP-1)水平,用彩色多普勒超声检测颈总动脉、颈内动脉颅外段及分叉处的内-中膜厚度(intima-media thickness,IMT),测量动脉粥样硬化(Athrosclerotic plaque,ASP)斑块面积占血管管腔总面积的百分比;并分析Ghrelin水平与炎性因子及颈动脉斑块之间关系。结果血浆炎性因子随着血清Ghrelin水平增加而降低,差异有统计学意义(P<0.05);对照组IMT明显增厚,颈动脉粥样硬化斑块检出及不稳定性斑块发生率高于治疗组,差异有统计学意义(P<0.05)。结论急性脑梗死患者的血清Ghrelin水平与炎性因子及颈动脉斑块显著相关,Ghrelin可能是急性脑梗死患者的一个重要保护因子。

Objective To investigate the relationship between serum concentraion of Ghrelin and inflammatory factors and Atherosclerotic plaque of patients with Acute ischemic stroke. Methods Selected 122 patiens with acute ischemic stroke who had been hospitalized in our deparment from January 2014 to January 2016. According to the serum level of Ghrelin（ 117. 0 ± 37. 2 pmol/l）,the patients were divided into treatment group 61 patients whose level of Ghrelin more than 117. 0 ＋ 37. 2 pmol/L and contral group 61 patient whose level of Ghrelin less than 117. 0 ＋ 37. 2 pmol/L randomly.Carotid artery was evaluated by color D oppler ultrasound in all study objects. Spontaneously,measured the level of TNFα（ Tumor necrosis factor-alpha）,IL-8（ Interleukin-8）,MCP-1（ monocyte chemotactic protein-1） by ELISA and analized the relationship between Ghrelin and inflammatory facors. Results The level of inflammatory factors attenutated according to increasing of Ghrelin; The IMT of contral group thicker than treatment and the test rates of IMT and unstable plaque were significantly higher than treantment group; The results were statistically remarkably.Conclusion The serum level of Ghrelin had notable relation with inflammatory factors and athrosclerotic plaque,which would be an important protective factor on acute ischemic stroke.