BRAF突变的肺癌患者腋窝淋巴结转移规律研究

Investigation of patterns of nodal metastases in BRAF mutant lung cancer

目的探究在肺癌,特别是非小细胞肺癌(NSCLC)中BRAF突变与非BRAF突变患者腋窝淋巴结(ax LN)转移发生率的差异。方法回顾性研究郑州大学第一附属医院2015年4月—2017年7月收治的64例BRAF突变肺癌患者的临床资料,统计BRAF突变的患者在治疗过程中出现ax LN转移的例数,计算其发生率,同时计算240例随机选取的非BRAF突变肺癌患者的ax LN转移发生率,运用χ~2检验分析两组资料的差异。结果 BRAF突变的肺癌患者ax LN转移发生率为14.1%(9/64),非BRAF突变的肺癌患者ax LN转移发生率为5.8%(14/240),二者差异有统计学意义(P=0.027)。结论 BRAF突变的肺癌患者ax LN转移发生率高于非BRAF突变患者。

Objective To investigate the difference in the incidence of axillary lymph node（ ax LN） metastases between BRAF and non-BRAF mutations in lung cancer,especially in non-small cell lung cancer（ NSCLC）. Methods The clinical data of 64 BRAF mutated patients with lung cancer was retrospective study,the incidence of ax LN metastases in patients with BRAF mutations and their incidence was calculated. The incidence of ax LN metastases in 240 randomly selected patients with non-BRAF lung cancer was also calculated,the differences between the two groups of data were compared by chi-square test. Results The incidence of ax LN metastases were 14. 1%（ 9/64） in patients with BRAF mutant lung cancer and 5. 8%（ 14/240） in patients with lung cancer without BRAF mutation. There was a significant difference between the two groups（ P = 0. 027）. Conclusion The incidence of ax LN metastases in BRAF-mutated lung cancer patients is higher than in non-BRAF patients.