康艾注射液治疗子宫颈癌术后疗效及对IGF-2、SCC、CYFRA21-1水平变化的影响

Kang’ai Injection on Cervical Cancer after Surgery and The Influence on IGF-2,SCC and CYFRA21-1

目的：分析康艾注射液对子宫颈癌术后患者的疗效及对IGF-2、SCC、CYFRA21-1水平变化的影响。方法：子宫颈癌患者91例,根据随机数字法分为对照组和观察组。所有患者术前均采用新辅助化疗后行全麻下开腹根治性宫颈切除手术治疗,对照组患者术后采用常规对症治疗,观察组患者在对照组治疗基础上加用康艾注射液治疗。观察两组患者治疗后疗效,健康状况、Th1/Th2细胞相关因子、IGF-2、SCC、CYFRA21-1水平变化情况。结果：观察组患者有效率为71.74%,对照组为48.89%,观察组患者有效率高于对照组（P〈0.05）。两组患者治疗后IGF-2、SCC、CYFRA21-1、IL-6和IL-10水平均较治疗前下降,INF-γ和IL-2水平均较治疗前上升（P〈0.05）。观察组患者治疗后IGF-2、SCC、CYFRA21-1、血清Th1/Th2细胞相关因子水平均优于对照组（P〈0.05）。观察组患者治疗后健康状况优于对照组（P〈0.05）。结论：子宫颈癌术后采用康艾注射液治疗可降低患者血清IGF-2、SCC、CYFRA21-1水平,调节患者血清Th1/Th2细胞相关因子水平,提高近期疗效,改善机体健康状况。

Objective： To analyze the influence of Kang＇ai Injection on cervical cancer postoperative serum insulin-like growth factor-2（ IGF-2）,squamous cell carcinoma（ SCC）,antibiotics,cytokeratin 19 fragment antigen（ CYFRA21-1） levels and clinical therapeutic effect. Methods： Ninety-one patients with cervical cancer were randomly divided into control group and observation group. All the patients were under general anesthesia with neoadjuvant chemotherapy underwent open radical resection of cervical surgery in the patients with symptomatic treatment. The observation group on the basic treatment used Kang＇ai Injection. The curative effect was observed after treatment in two groups. The health status,Th1/Th2 related cytokines,IGF-2,SCC and CYFRA21-1 level changes were observed. Results： The effective rate in the observation group was 71. 74% and the control group＇s was 48. 89%. The observation group＇s was higher than that of the control group（ P 〈0. 05）. The two groups＇ IGF-2,SCC,CYFRA21-1,IL-6 and IL-10 levels after treatment were lower than that before treatment. INF-γ and IL-2 levels significantly increased（ P 〈0. 05）.The observation group＇s IGF-2,SCC,CYFRA21-1 correlation factor of serum levels of Th1/Th2 cells after treatment were better than those of the control group（ P 〈0. 05）. The observation group＇s health status was better than that of the control group（ P〈 0. 05）. Conclusion： Kang＇ai Injection can reduce the serum IGF-2,SCC and CYFRA21-1,regulate Th1/Th2 cytokines levels in serum of patients and improve the curative effect and the health status of the body.