枳苓化浊解毒汤联合穴位敷贴治疗慢性萎缩性胃炎的疗效及对胃动力和炎性因子水平的影响

Zhiling Huazhuo Jiedu Decoction Combined with Acupoint Application Therapy and Effect of CAG on Gastric Motility and Inflammatory Factor Levels

目的：探讨自拟枳苓化浊解毒汤联合穴位敷贴治疗慢性萎缩性胃炎（CAG）的疗效及对胃动力和炎性因子水平的影响。方法：慢性萎缩性胃炎患者157例,根据治疗方法不同分为对照组和观察组。对照组患者给予多潘立酮片及抑酸等基础西药治疗,观察组患者在对照组西药治疗的基础上给予枳苓化浊解毒汤联合穴位敷贴治疗。观察并比较两组患者胃动力情况、症状改善情况、胃镜检查结果改善情况及炎性因子变化水平。结果：两组患者治疗后胃泌素、P及F水平均较治疗前上升,观察组患者治疗后胃泌素水平高于对照组患者治疗后（P〈0.05）。两组患者治疗后P和F水平比较无统计学差异（P〉0.05）。两组患者治疗后胃脘痞满、胃脘隐痛、嗳气、大便稀溏、胃寒怕冷、泛酸及食欲减退症状积分均较治疗前下降,观察组患者治疗后胃脘痞满、胃脘隐痛、嗳气、大便稀溏及胃寒怕冷症状积分低于对照组患者治疗后（P〈0.05）。两组患者治疗后泛酸和食欲减退症状积分比较无统计学差异（P〉0.05）。两组患者治疗后IL-6、TNF-α及s Ig A水平均较治疗前下降,观察组患者治疗后IL-6、TNF-α及s Ig A水平低于对照组患者治疗后（P〈0.05）。两组患者治疗后胃镜检查黏膜颗粒状、黏膜皱壁变薄、结膜血管显露及黏膜色泽灰暗所占例数均较治疗前下降,观察组患者治疗后胃镜检查黏膜颗粒状、黏膜皱壁变薄、结膜血管显露及黏膜色泽灰暗所占例数少于对照组患者治疗后（P〈0.05）。结论：枳苓化浊解毒汤联合穴位敷贴治疗慢性萎缩性胃炎可有效改善患者临床症状和胃镜表现,降低炎性因子水平,增加患者胃泌素分泌,增强胃窦收缩力,促进胃排空。

Objective： To observe the effects of Zhiling Huazhuo Jiedu Decoction combined with acupoint application in the treatment of chronic atrophic gastritis（ CAG） and effect on gastric motility and inflammatory factor levels. Methods： A total of 157 patients with chronic atrophic gastritis were retrospectively selected,and according to the different treatment methods were divided into observation group and control group. The control group was treated with acid suppression and Domperidone Tablets and on the basis of Western medicine treatment,patients in the observation group were treated with Western medicine and Zhiling Huazhuo Jiedu Decoction combined with acupoint application therapy. The two groups were observed and compared the gastric motility,improvement of symptoms,gastroscopy results improvement and changes of inflammatory cytokines. Results： After treatment,two groups＇ gastrin,P and F were compared with those before treatment. The observation group＇s gastrin levels after treatment were higher than that of the control group（ P 〈0. 05）. There was no significant differences between the two groups＇ P and F after treatment（ P〉 0. 05）. Two groups＇ epigastric fullness,epigastric pain,belching,loose stool,stomach cold,pantothenic acid and anorexia symptom scores after treatment were lower than those before treatment. The observation group＇s epigastric fullness,epigastric pain,belching,loose stool and stomach cold symptoms score were lower than those in the control group after treatment（ P 〈0. 05）. Two groups＇ pantothenic acid and anorexia symptom scores after treatment showed no significant difference（ P〉 0. 05）. Two groups＇ IL-6,TNF-α and s Ig A levels after treatment were lower than those before treatment. The observation group＇s IL-6,TNF-α and s Ig A after treatment were lower than those of the control group（ P 〈0. 05）. Two groups ＇gastroscopy showed mucosa granular,mucosa plica becoming thin,conjunctival vessels revealed mucosa and the number of cases for dark gray color after treatment was lower than those before treatment. The observation group＇s gastroscopy showed granular,mucous membrane wrinkle wall thinning,the number of cases for the conjunctival vessels revealed mucosa and dark gray color was less than that of the control group after treatment（ P〈 0. 05）. Conclusion： The treatment of chronic atrophic gastritis can effectively improve the clinical symptoms and gastroscopy in patients with self-made Zhiling Huazhuo Jiedu Decoction combined with acupoint application,reduce the levels of inflammatory factors,improve patients＇ gastrin,enhance antral contraction and promote gastric emptying.