伊伐布雷定联合持续性气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并心律失常的临床效果

Clinical effect of Ivabradine combined with continuous positive airway pressure ventilation in the treatment of obstructive sleep apnea-hypopnea syndrome complicated with arrhythmia

目的观察伊伐布雷定联合持续性气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并心律失常的临床效果。方法选取化州市人民医院2015年3月~2017年4月收治的112例阻塞性睡眠呼吸暂停综合征合并心律失常患者,使用持续性气道正压通气治疗者为对照组,联合使用伊伐布雷定和持续性气道正压通气治疗者为观察组,每组56例。两组均治疗30 d。比较两组的LAT、MAT、AHI、mSaO_2,最高心率、最低心率、心律失常率。结果治疗后,两组患者的LAT、MAT、AHI、mSaO_2,最高心率、最低心率、心律失常率均有所改善,差异有统计学意义(P<0.05)。观察组治疗后的AHI明显低于对照组,mSaO_2明显高于对照组,心律失常率与治疗前比较,明显低于对照组,差异均有统计学意义(P<0.05)。结论伊伐布雷定联合持续性气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并心律失常的临床效果更显著,可有效改善患者的心律失常。

Objective To observe the clinical effect of Ivabradine combined with continuous positive airway pressure ventilation in the treatment of obstructive sleep apnea-hypopnea syndrome complicated with arrhythmia. Methods A total of 112 patients with obstructive sleep apnea-hypopnea syndrome with arrhythmia were treated in Huazhou People′s Hospital from March 2015 to April 2017 were selected. The patients treated with continuous positive airway pressure ventilation were selected as the control group, while the patients treated with Ivabradine combined with continuous positive airway pressure ventilation were selected as the observation group, and there were 56 patients in each group. The two groups were treated for 30 days. LAT, MAT, AHI, mSaO_2, maximum heart rate, minimum heart rate, and arrhythmia rate were compared between the two groups. Results After treatment, the LAT, MAT, AHI, mSaO_2, maximum heart rate,minimum heart rate, and arrhythmia rate in the two groups were improved compared with before treatment, and the differences were statistically significant（P〈0.05）. After treatment, AHI of the observation group was significantly lower than that of the control group, mSaO_2 was significantly higher than that of control group, average arrhythmia rate was significantly lower than that of the control group, and the differences were statistically significant（P〈0.05）. Conclusion The clinical effect of Ivabradine combined with continuous positive airway pressure ventilation in the treatment of obstructive sleep apnea-hypopnea syndrome with arrhythmia is more significant, and it can effectively improve the arrhythmia of the patients.