基于中医传承辅助系统的湿疹外治方剂组方配伍规律研究

Study on composition principles of the traditional Chinese medicine external prescriptions for eczema by datamining methods

目的 探讨中医湿疹外治方剂的组方配伍规律。方法 检索中国期刊全文数据库（CNKI）、中文科技期刊数据库（重庆维普）、中国学术期刊数据库（万方数据）、中国生物医学文献服务系统（SinoMed）建库至2016年12月31日收录的湿疹外治方剂，利用中医传承辅助平台（V1.1）软件构建数据库，采用频数分析、关联规则、复杂系统聚类分析等数据挖掘技术，对湿疹外治方剂进行分析。结果 共筛选出湿疹外治方剂51首，涉及中药148种；其中出现频次≥8次的药物有16种，药物组合22个（支持度8），关联规则4条（支持度8，置信度0.8），核心药物组合7个（相关度8，惩罚度8），衍化出1个新方剂。结论 湿疹外治方剂主要以清热药，尤其是清热燥湿药为主，辅以养血凉血祛风利湿药。

To analyze the composing principles of the traditional Chinese medicine （TCM） prescriptions for eczema by data mining methods. Methods The CNKI, VIP, Wanfang and SinoMed from inception to the December 31st 2016 were searched, which were collected into the traditional Chinese medicine inheritance support system （TCMISS） and analyzed by data mining methods, which included frequency analysis, Cluster Analysis and correlation rules. Results Based on the analysis of 51 cases of TCM prescriptions reported in literatures, 16 herbs （frequency≥8） were found frequently used. And the results showed that 22 combination herbs （supporting coefficient=8）, 4 association rules （supporting coefficient=8 and confidence coefficient=0.8）, 7 core combinations and 1 new TCM prescription were found. Conclusions The TCM prescriptions for eczema are mainly composed of herbs with heat-clearing effect, especially with damp-drying effect, supplemented by herbs with blood-nourishing, blood-cooling and rheumatism effects.