三伏贴、三九贴治疗小儿哮喘的疗效及对IgG、IgA、IgM的影响

The Curative Effect of the Sanfu Plaster and Sanjiu Plaster in the Treatment of Asthma in Children and the Influence on IgG, IgA and IgM

目的探讨三伏贴、三九贴治疗小儿哮喘的疗效及对IgG、IgA、IgM的影响。方法回顾性选取2013年2月—2015年6月收治的哮喘患儿76例,根据治疗方法不同分为对照组和观察组。对照组患儿给予常规药物治疗,观察组患儿于每年三伏期间给予三伏贴贴敷于相应穴位,于每年三九期间给予三九贴贴敷于相应穴位。观察并比较2组患儿临床疗效、中医症状评分及相关实验室指标水平变化情况。结果 2组患儿治疗后哮喘发作次数有所减少,病情程度有所减轻,中医症状评分有所下降(P<0.05)。观察组患儿治疗后的哮喘发作次数,病情程度和中医症状评分均优于对照组(P<0.05)。2组患儿治疗后IgG和IgA水平均有所升高,观察组患儿IgG和IgA水平高于对照组(P<0.05)。2组患儿治疗后IgM水平略有上升,但无统计学差异(P>0.05)。2组患儿治疗后EOS和c GMP水平有所下降,Cor和c AMP水平上升(P<0.05)。观察组患儿EOS水平低于对照组,Cor和c AMP水平高于对照组(P<0.05)。2组患儿治疗后c GMP水平比较无统计学差异(P>0.05)。结论三伏贴、三九贴治疗小儿哮喘的疗效明显,可降低哮喘发病率,增强机体免疫功能,调节机体Cor、c AMP和c GMP水平。

Objective To explore the effect of Sanfu plaster and Sanjiu plaster in the treatment of asthma in children and the influence on IgG, IgA and IgM. Methods A retrospective selection of 76 cases of children with asthma from February 2013 to June 2015 in our hospital was made. According to the different treatinent methods, they were divided into observation group and control group. The children in the control group were treated with placebo, and the children in the observation group were given Sanfu plaster and Sanjiu plaster to the corresponding acupoints during the period of each year. The clinical efficacy, symptom score and related laboratory indexes of the two groups were observed and compared. Results After treatment, the number of asthma severity, mitigated and TCM symptom score decreased （P〈0.05） . The number of episodes of asthma in the observation group decreased, and the degree of disease and the symptom score of TCM in the observation group were better than those in the control group （P〈0.05） . The levels of IgG and IgA were elevated in the two groups after treatinent, and the levels of IgG and IgA in the observation group were higher than those in the control group （P〈0.05） . The level of IgM increased slightly in the two groups after treatment, but there was no statistical difference （P〉0.05） . After treatment, the levels of EOS and cGMP decreased, and the levels of Cor and cAMP increased in the two groups （P〈0.05） . The level of EOS in the observation group was lower than that in the control group, and the levels of Cor and cAMP of the observation group were higher than those of the control group （P〈0.05） . There was no significant difference in cGMP levels between the two groups after treatment （P〉0.05） . Conclusion The Sanfu plaster and Sanjiu plaster in the treatment of asthma in children has significant effect, which can reduce the incidence of asthma, enhance the immune function of the body, and regulate the level of Cor, cAMP and cGMP.