复方佛耳草合剂对慢性阻塞性肺疾病急性加重患者气道炎症的影响

Effects of Compound FoErCao Mixture on Airway Inflammation of AECOPD Patients

目的:观察复方佛耳草合剂对慢性阻塞性肺疾病(COPD)急性加重患者气道炎症的影响。方法:将COPD急性加重患者107例随机分为治疗组51例和对照组56例。2组常规治疗后,对照组给予复方佛耳草合剂模拟剂,治疗组给予复方佛耳草合剂,均服用14天。观察2组患者主要症状缓解起效时间、肺功能指标、炎症因子水平变化情况。结果:1)治疗后2组患者主要症状(咳嗽、咯痰)缓解起效时间比较差异具有统计学意义(P<0. 05);2) 2组患者第1秒用力呼气容积(FEV_1)、第1秒用力呼气容积占预计值百分比(FEV_1%)、用力肺活量(FVC)均较治疗前改善,差异有统计学意义(P<0. 05)。治疗后2组患者FEV_1、FEV_1%、FVC比较差异具有统计学意义(P<0. 05)。3)治疗后2组患者白细胞介素8(I L-8)水平较治疗前降低,差异有统计学意义(P<0. 05),治疗后2组患者I L-8水平比较差异具有统计学意义(P<0. 05)。4)肺功能指标与炎症因子I L-8水平呈负相关。结论:复方佛耳草合剂联合西药治疗可迅速缓解患者咳嗽、咯痰症状,降低炎症因子水平,改善患者肺通气指标。

Objective： To observe the effects of compound FoErCao mixture on airway inflammation of thepatients with acute exbaceration chronic obstructive pulmonary disease （AECOPD）. Methods： All 107 AECOPDpatients were randomized into 51 cases of the treatment group and 56 cases of the control group. After conventionaltherapy, the control group accepted the placebo of compound FoErCao mixture, and the treatment group tookcompound FoErCao mixture, they took for 14 days consecutively. The changes of inflammatory factors levels, theindexes of pulmonary function and the onset time of main symptoms of the patients were observed. Results： 1） Thedifference had statistical meaning in the comparisons of the onset time of main symptoms （cough and coughing upphlegm） between both groups after treating（P〈0.05）; 2） FEV1, FEV1% and FVC of both groups were improvedcompared with before treating, and the difference had statistical meaning（P〈0.05）. The difference showed statisticalmeaning in the comparisons of FEV1, FEV1% and FVC between both groups after treating（P〈0.05）. 3） The levels ofIL-8 decreased after treating in both groups compared with before treating, and there was a significant difference（P〈0.05）, the difference was statistically significant in the comparisons of the levels of IL-8 between both groupsafter treating（P〈0.05）. 4）The indexes of pulmonary function were negatively related to the levels of IL-8.Conclusion： Compound FoErCao mixture in combination with western medicine could rapidly relieve the symptomssuch as cough, coughing up phlegm of the patients, lower the level of inflammatory factors and improve the indexesof pulmonary ventilation.