良性甲状腺结节患者血清维生素水平与中医辨证分型的相关性

The Correlation between TCM Syndrome Differentiation and Patterns and the Level of Vitamin of the Patients with Benign Thyroid Nodule

目的:探讨体内维生素水平与良性阶段甲状腺结节的相关性,以及不同中医证型患者维生素水平的差异性。方法:通过超声检查将疑似良性甲状腺结节患者84例分为正常甲状腺的对照组21例及良性甲状腺结节患者的病例组63例,采用中医辨证方法将病例组分为肝郁气滞证35例、肾气虚证14例、肾阴虚证14例;比较各组血清维生素A(VitA),维生素D(VitD),维生素E(VitE),维生素B_1(VitB_1),维生素B_2(VitB_2),维生素B_6(VitB_6),维生素B_9(VitB_9),维生素C(VitC)水平的差异。结果:VitA、VitD、VitE、VitB_1、VitB_2、VitC水平各组间比较差异无统计学意义(P>0. 05),VitB_6水平病例组低于对照组(P<0. 05)。肝郁气滞证患者VitB_6水平低于对照组(P<0. 01),VitB_9水平低于肾气虚证与肾阴虚证患者(P<0. 05)。结论:低VitB_6水平与良性甲状腺结节有关,低VitB_6水平成为肝郁气滞证区别于其他证型的特征,可为肝郁气滞证的辨病基础。低VitB_9水平与肝郁气滞证相关。低VitB_6和VitB_9水平可为良性甲状腺结节中医辨病与辨证用药提供依据。

Objective： To discuss the correlation between the level of vitamin and benign thyroid nodule, andthe difference of the levels of vitamin of the patients with different TCM patterns. Methods： All 84 patients whowere proved with benign thyroid nodule by ultrasonic examination were separated into 21 cases of the control group（normal thyroid） and 63 cases of the medical cases group （benign thyroid nodule）, medical cases group was dividedinto 35 cases of liver depression and Qi stagnation pattern, 14 cases of renal Qi deficiency pattern and 14 cases ofrenal Yin deficiency pattern; to compare the levels of vitamin A （VitA）, vitamin D （VitD）, vitamin E （VitE）, vitaminB1 （VitB1）, vitaminB2 （VitB2）, vitaminB6 （VitB6）,vitaminB9 （VitB9）,vitamin C（VitC） in different groups. Results：There was no statistical difference in the comparisons of the levels of VitA, VitD, VitE, VitB1, VitB2 and VitCamong the groups（P〉0.05）, medical cases group was lower than the control group in the level of VitB6 （P〈0.05）,the patients of liver depression and Qi stagnation pattern were lower than the control group in the level of VitB6（P〈0.01）, lower than the patients of renal Qi deficiency pattern and renal Yin deficiency pattern in the level of VitB9（P〈0.05）. Conclusion： Low level of VitB6 is related to benign thyroid nodule, low level of VitB6 become the featurethat distinguished liver depression and Qi stagnation pattern from other patterns, which could be taken as the basis of syndrome differentiation of liver depression and Qi stagnation pattern. Low level of VitB9 is connected to liverdepression and Qi stagnation pattern. Low level of VitB6 and VitB9 could provide the reference for disease differen-tiation, syndrome differentiation and pharmacy of benign thyroid nodule.