中药调理体质治疗中重度持续性变应性鼻炎的临床观察

Clinical Observation on Patients with Moderate-severe Persistent Allergic Rhinitis Treated by Regulating Constitution with Traditional Chinese Medicine

目的观察中药调理体质对中重度持续性变应性鼻炎患者临床疗效及生活质量的影响。方法将121例阳虚质、气虚质中重度持续性变应性鼻炎患者随机分为治疗组(61例)和对照组(60例),治疗组给予中药免煎颗粒调理体质联合西药常规治疗,对照组给予西药常规治疗,疗程4周,随访6个月。观察两组患者治疗4周及随访6个月时鼻部症状[采用视觉模拟量表(VAS)总评分、生活质量总评分]及临床疗效。结果与本组治疗前比较,两组患者治疗4周、随访6个月时VAS和RQLQ总评分均降低(P<0.05),随访6个月时对照组VAS及RQLQ总评分较4周时有升高(P<0.05);与对照组同期比较,治疗组患者治疗4周及随访6个月时VAS总评分及RQLQ总评分均降低(P<0.05)。治疗4周时及随访6个月时治疗组总有效率分别为91.80%、85.25%,对照组分别为76.67%、56.67%,与本组治疗4周时比较,随访6个月时对照组总有效率降低(P<0.05);与对照组同期比较,治疗组总有效率均提高(P<0.05)。两组患者在治疗过程中不良反应发生率差异无统计学意义(P>0.05),均未出现鼻中隔穿孔、腹泻、腹痛、食欲减退及皮疹等不良反应。结论通过中药调理体质治疗中重度持续性变应性鼻炎患者可以提高临床疗效,改善患者的生活质量。

Objective To observe the influence on clinical efficacy and the quality of life of pa- tients with moderate-severe persistent allergic rhinitis（AR） by regulating constitution with traditional Chi- nese medicine （TCM）. Methods Totally 121 moderate-severe persistent AR patients with constitution of Yang deficiency, Qi deficiency were randomly assigned to treatment group （61 cases） and control group （60 cases）. Patients in the treatment group were treated with TCM Granule in combination with conven- tional Western medicine, while patients in the control group treated with conventional Western medicine therapy. The therapy course was 4 weeks and follow-up for 6 months was performed. The changes of na- sal symptoms Eincluding the total score of Visual Analogue Scale （VAS） and rhino conjunctivitis quality of life questionnaire （RQLQ） ] and clinical efficacy were observed at week 4 of treatment and month 6 of follow-ups. Results Compared with before treatment, the total score of VAS and RQLQ were reduced in both groups at week 4 and month 6 （P 〈0.05）, but VAS and RQLQ total score increased in control group at month 6（P 〈0.05）. Compared with the same period, the total score of VAS and RQLQ in treatment group were lower than those in control group at week 4 and month 6（P 〈0.05）. The total efficiency in treatment group were 91.80% and 85.25% respectively at week 4 and month 6, while 76.67% and 56.67% respectively in control group, the total efficiency in control group was decreased at month 6 than that at week 4 （P 〈0.05） ,compared with the control group, the total efficiency of treatment group was in- creased（P 〈0.05）. There was no significant difference in adverse reaction rate between the two groups during the course of treatment（P 〉0.05）. No other adverse reactions such as perforation of the nasal sep- tum, diarrhea, abdominal pain, loss of appetite and rash occurred were observed. Conclusion Treating patients with moderate-severe persistent AR by regulating constitution with TCM could improve clinical effects and improve quality of life of patients.