心血管疾病中医药调节的“新靶点”:自噬——由2016年诺贝尔医学奖引发的思考

A Novel Therapeutic Target of Chinese Medicine for Cardiovascular Diseases:Autophagy—Prospective from the Nobel Prize in Medicine in 2016

心血管疾病是我国居民首要死亡原因。目前,基于"病证结合"的中西医结合治疗已经成为心血管疾病的主要治疗模式,中医药干预能够延缓心血管疾病的进程,改善生活质量和降低心血管事件的发生率。然而,中医药治疗心血管疾病的靶点与机制还不够明确。研究表明,自噬对心血管疾病如心肌梗死、心力衰竭等的发生、发展有重要作用,是调节心血管疾病的"新靶点"。本文对中医药通过自噬调节心血管疾病的研究进行述评,为中医药治疗心血管疾病提供依据。

Cardiovascular disease （CVD） is the leading cause of mortality in China. Currently, integrative medicine based on the combination of disease and syndrome has being grown to the main healthcare system for cardiovascular diseases. Furthermore, increasing evidences showed Chinese medicine （CM） was beneficial in alleviating the syndromes and improving quality of life for the patients with CVD, as well as reducing the incidence of major adverse cardiovascular events in the long term. However, it is uncertain for the therapeutic targets and mechanisms of the CM for CVD. Recent resear- ches demonstrated that autophagy played an important role in the development of CVD such as myocar- dial infarction （MI） and heart failure. Consequently, autophagy is a novel therapeutic target for CVD. This paper reviews the study of CM relating with CVD via autophagy, thus providing new evidence for the treatment of cardiovascular diseases with CM.