摘要
目的研究N-甲基-N-苯甲酰甲基-α,β-环氧-β-苯基丙酰胺合成方法的改进。方法以N-甲基-N-[(β-羟基-β-苯基)-乙基]-α,β-环氧-β-苯基丙酰胺为原料,二氯异氰尿酸钠为氧化剂在2,2,6,6-四甲基哌啶氧化物催化下氧化得到产物。结果合成工艺收率为87.5%。结论所用制备方法简单、产率良好,适合大量制备。
Objective To study the synthesis of N-methyl-N-benzoylmethyl-α,β-epoxy-β-phenylpropanamide. Methods Oxidation of N-methyl-N-[(β-hydroxy -β-phenyl)-ethyl]-α,β-epoxy-β-phenylpropionamide with sodium dichloroisocyanurate and catalyzed by 2,2,6,6-tetramethylpiperidine oxide gave product. Results The synthetic process yield is 87.5%.Conclusion The preparation method is simple and the yield is good. It is suitable for large scale preparation.
作者
米俊儒
林汉森
Mi Junru;Lin Hansen(School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China)
出处
《广东化工》
CAS
2018年第18期29-29,61,共2页
Guangdong Chemical Industry
关键词
黄皮酰胺
氧化反应
二氯异氰尿酸钠
Clausenamide
oxidation reaction
sodium dichloroisocyanurate