N-甲基-N-苯甲酰甲基-α,β-环氧-β-苯基丙酰胺的合成方法改进

An Improved Synthesis of N-methyl-N-benzoylmethyl-α,β-epoxy-β-phenylpropionamide

目的研究N-甲基-N-苯甲酰甲基-α,β-环氧-β-苯基丙酰胺合成方法的改进。方法以N-甲基-N-[(β-羟基-β-苯基)-乙基]-α,β-环氧-β-苯基丙酰胺为原料,二氯异氰尿酸钠为氧化剂在2,2,6,6-四甲基哌啶氧化物催化下氧化得到产物。结果合成工艺收率为87.5%。结论所用制备方法简单、产率良好,适合大量制备。

Objective To study the synthesis of N-methyl-N-benzoylmethyl-α,β-epoxy-β-phenylpropanamide. Methods Oxidation of N-methyl-N-[（β-hydroxy -β-phenyl）-ethyl]-α,β-epoxy-β-phenylpropionamide with sodium dichloroisocyanurate and catalyzed by 2,2,6,6-tetramethylpiperidine oxide gave product. Results The synthetic process yield is 87.5%.Conclusion The preparation method is simple and the yield is good. It is suitable for large scale preparation.