炎性细胞因子白细胞介素-1β和肿瘤坏死因子-α与大骨节病关系的研究进展

Progression of inflammatory factors IL-1β and TNF-α in Kashin-Beck disease

炎性因子是能引起组织和细胞损伤而导致炎症的因子，如白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）。炎性因子IL-1β、TNF-α与大骨节病（Kashin-Beck disease，KBD）的软骨损伤关系较为密切。研究IL-1β、TNF-α有助于探讨KBD的发生及发展中的炎性反应作用，找寻环境危险因素与环境反应基因、蛋白的相互作用，发现KBD防治中的有效基因、蛋白和通路。

Inflammatory factor can cause tissue and cell damage and induce inflammatory reaction, such as production of interleukin-1β （IL-1β） and tumor necrosis factor-α （TNF-α）. Many studies have found that there was a close relationship between the two factors and Kashin-Beck disease （KBD） cartilage damage. The research on TNF-α and IL-1β could help probing the inflammatory reaction during KBD development and occurrence, and finding the interaction between environmental risk factors and environmental reaction gene and protein, then finding effective gene, protein and pathway for KBD prevention and control.