五苓散对非酒精性脂肪肝病患者血清瘦素水平及胰岛素抵抗指数的影响

Effect of Wuling Powder on Serum Leptin Level and Insulin Resistance Index in Patients with Nonalcoholic Fatty Liver Disease

目的观察五苓散对非酒精性脂肪肝病患者血清瘦素水平及胰岛素抵抗指数的影响。方法将84例患者随机分成治疗组及对照组(每组42例),治疗组予以五苓散,对照组予以多烯磷脂酰胆碱胶囊,疗程为3个月。检测治疗前后肝功能(ALT、AST)、总胆固醇(TC)、甘油三酯(TG)、瘦素、脂联素、空腹血糖及胰岛素水平并计算胰岛素抵抗指数。结果治疗组的总有效率为81.0%,优于对照组的69.0%(P<0.05)。治疗后,治疗组肝功指标(ALT、AST)、TC、TG、瘦素及HOMA-IR的下降明显优于对照组的(P<0.05);2组的脂联素均升高,组间差异无统计学意义(P>0.05)。结论五苓散对非酒精性脂肪肝病患者疗效显著,可能通过降低血清瘦素水平、改善胰岛素抵抗等途径来实现。

Objective To observe the effect of Wuling powder on serum leptin level and insulin resistance index in patients with nonalcoholic fatty liver disease. Methods 84 patients were randomly divided into experiment group and control group, and each group had 48 cases. Patients in experiment group were treated by Wuling powder, while patients in control group were treated with polyene phosphatidyl choline. The treatment continued for 3 months. The contents of ALT, AST, TC, TG, leptin （LP）, adiponectin （APN）, FBG and INS in serum of all patients were measured before and after treatment, HOMA-IR was calculated by FBG and INS. Results The total effective rate of experiment group was significantly higher than control group （ 81.0% vs 69.0% , P 〈 0. 05）. After treatment, the content of ALT, AST, CHOL, TC, TG,LP and HOMA-IR in the experiment group reduced significantly comparing with those in control group （P 〈 0. 05 ）. APN level were significantly improved in each group, but there was no statistical difference between groups （P 〉 0.05 ）. Conclusion Wuling powder can effectively treat nonalcoholic fatty liver disease probably by decreasing serum leptin and improving insulin resistance.