美沙酮和羟考酮治疗中重度癌痛的优劣差异

The differences of advantages and disadvantages between Methadone and Oxycodone in the treatment of moderate and severe cancer pain

目的分析美沙酮和羟考酮治疗中重度癌痛的临床效果差异。方法 80例癌症晚期伴中重度癌痛患者,采用随机数字表法分为A组和B组,各40例。A组患者给予羟考酮治疗,B组患者给予美沙酮治疗。比较两组患者的镇痛效果及用药后不良反应发生情况。结果 A组患者的镇痛有效率为92.5%,高于B组患者的75.0%,差异具有统计学意义(P<0.05)。两组患者均出现了便秘、头晕、嗜睡等药物不良反应,A组患者的不良反应率为15.0%,明显低于B组的35.0%,差异具有统计学意义(P<0.05)。结论美沙酮及羟考酮均可有效地缓解癌症晚期患者的癌痛症状,提高患者的生活质量,但羟考酮的镇痛有效率更高,且不良反应更少,具有更好的临床效果。

Objective To analyze the difference of clinical effect between Methadone and Oxycodone in the treatment of moderate and severe cancer pain. Methods A total of 80 patients with advanced cancer accompanied by moderate or severe cancer pain were divided into group A and group B according to the random number table method, 40 cases in each group. Group A was treated with Oxyeodone and group B was treated with Methadone. The analgesic effect and adverse reactions after medication between the two groups were compared. Results The effective rate of analgesia in group A was 92.5%, which was significantly higher than 75.0% in group B, the difference was statistically significant （P〈O.05）. The adverse drug reactions such as constipation, dizziness and drowsiness occurred in both groups. The rate of adverse reactions in group A was 15.0%, which was significantly lower than 35.0% in group B, the difference was statistically significant （P〈O.05）. Conclusion Methadone and Oxycodone can effectively alleviate cancer pain symptoms of patients with advanced cancer, improve the quality of life of patients, but Oxycodone has higher analgesic efficiency and less adverse reactions, it has better clinical effect.