矮小症儿童GH缺乏与25-（OH）D水平的相关分析

Correlation between 25-hydroxy vitamin D and growth hormone deficiency in short stature children

目的：探讨矮小症儿童生长激素（growth hormone,GH）激发试验结果与体内25-（OH）维生素D[25-hydroxy;vitamin;D,25-（OH）D]）浓度的相关性.方法：对271例矮小症患儿进行左旋多巴与精氨酸联合激发试验,采用化学发光法进行血清GH、25-（OH）维生素D检测.结果：生长激素峰值出现时间多在60min与90min.生长激素完全缺乏组中血清25-（OH）D浓度为15.90±5.24ng/mL,其25-（OH）D缺乏的发生率占72.94％,不足的发生率占25.88％;生长激素部分缺乏组中血清25-（OH）D浓度为19.35±6.63ng/mL,其25-（OH）D缺乏的发生率占61.05％,不足的发生率占30.53％;生长激素正常组中血清25-（OH）D浓度为19.22±7.15ng/mL,其25-（OH）D缺乏的发生率占51.65％,不足的发生率占45.05％.结论：矮小儿童体内存在不同程度的维生素D缺乏,其发生率在生长激素不同浓度组的矮小儿童中存在显著差异,矮小儿童应合理补充维生素D（vitaminSD,VitD）.

Objective： To investigate the correlation between the results of growth hormone provocation test and the values of 25- hydroxy vitamin D in short stature children. Methods： Totally 27l cases of short stature children were underwent arginine and levodopa provocation test. The levels of growth hormone and 25-hydroxy vitamin D were determined with chemiluminescent. Results： The peak value of growth hormone mostly focused on time 60 and 90 minutes. The level of 25-hydroxy vitamin D in the group of children who suspected GH complete deficiency was 15.90±5.24ng/mL, accounting for 72.94% in deficiency of 25-hydroxy vitamin D, and accounting for 25.88% in insufficiency of 25-hydroxy vitamin D. The level of 25-hydroxy vitamin D in the group of children who suspected GH part deficiency was 19.35±6.63ng/mL, accounting for 61.05% in deficiency of 25-hydroxy vitamin D, and accounting for 30.53% in insufficiency of 25-hydroxy vitamin D. The level of 25-hydroxy vitamin D in the group of healthy children was 19.22±7.15ng/mL, accounting for 51.65% in deficiency of 25-hydroxy vitamin D, and accounting for 45.05% in insufficiency of 25-hydroxy vitamin D. Conclusion： There were different levels for vitamin D deficiency in short stature children. Its incidence of vitamin D deficiency had significant difference in different levels of growth hormone. The vitamin D supplements should be reasonable for short stature children.