IL-6、WBC及PCT水平在胆道感染所致胆管良恶性狭窄中的诊断价值

Diagnostic value of IL-6, WBC and PCT levels in benign and malignant biliary strictures caused by biliary tract infection

目的：探讨IL-6、WBC、PCT水平在胆道感染所致胆管良恶性狭窄中的诊断价值.方法：选取2014年1月～2017年12月间我院收治的90例老年胆道感染所致胆道狭窄患者作为本组研究对象,检测受试者血常规,并采用酶联免疫吸附法检测血中IL-6及PCT水平;以病理学检测结果作为金标准分析各指标诊断鉴别价值.结果：恶性组患者血中PCT、IL-6及WBC指标均明显高于良性组,且差异存统计学意义（P〈0.05）;采用系列联合诊断灵敏度显著高于各指标单独诊断,采用平行联合诊断的特异度显著高于各指标单独诊断,平行联合及系列联合诊断的ROC曲线下面积均高于各指标单独诊断.结论：采用IL-6、WBC及PCT联合诊断鉴别胆道感染所致胆管良恶性狭窄时可提高诊断灵敏度及特异度,具有较高应用价值.

Objective： To explore the diagnostic value of IL-6, WBC and PCT levels in biliary tract benign and malignant stricture which caused by biliary tract infection. Methods： 90 elderly patients with biliary stricture caused by biliary tract infection who admitted to our hospital from January 2014 to December 2017 were selected as the subjects of this study. Blood routine was tested and serum IL-6 and PCT levels were detected by enzyme-linked immunosorbent assay Histopathological examination results were used as gold standard to analyze the diagnostic and differential value of each index. Results： PCT, IL-6 and WBC in the blood of patients in the malignant group were significantly higher than those in the benign group, and the difference was statistical significance （P〈0.05） ; The sensitivity of serial combined diagnosis was significantly higher than that of each indicator alone, and the specificity of parallel combined diagnosis was significantly higher than that of each indicator alone, and the area under the tkOC curve of parallel combined diagnosis and series combined diagnosis was higher than that of each index separately. Gonclusion： The combined diagnosis of IL-6, WBC and PCT in the differential diagnosis of benign and malignant biliary stricture caused by biliary tract infection can improve the diagnostic sensitivity and specificity, which is of high application value.