乳腺发育不良动物模型制备规范(草案)

Standard Specification for Animal Models of Mammary Dysplasia(Draft)

现代医学认为,乳腺发育不良的病因病机主要是由于雌激素水平过低,乳腺组织气血运行不顺畅,内分泌紊乱等原因造成,乳腺的生长分化主要受下丘脑-垂体-卵巢轴的调控。现行的乳腺发育不良动物模型制备方法有去势法和心理应激法,因此从乳腺发育不良中西医临床病症特点出发,对现有的乳腺发育不良动物模型制备方法进行归纳总结,探讨乳腺发育不良动物模型的制备规范,以期为乳腺发育不良的深入研究提供可靠的动物模型制备方法。

Modern medicine believes that the etiology and pathogenesis of mammary dysplasia is mainly caused by low level of estrogen,poor flowability of the blood in breast tissue,and the endocrine disorders.Growth and differentiation of mammary glands is mainly regulated by the hypothalamus-pituitary-ovarian axis.The current animal model preparation methods for mammary dysplasia include the castration and psychological stress method.The current article summarized the existing preparation methods of animal mammary dysplasia models from the aspects of mammary gland development characteristics of Chinese and western medicine clinical conditions,and discussed the specification for preparation of animal mammary dysplasia models,to provide reliable basis for the further study of the animal mammary dysplasia model preparation.