摘要
何首乌为蓼科植物何首乌Polygonum multiflorum Thunb.的干燥块根。何首乌含有蒽醌类、二苯乙烯苷类、黄酮类、磷脂类等多种类型的活性成分,具有抗衰老、增强免疫功能、降血脂、补血、抗动脉粥样硬化、抗菌等多方面的药理作用。何首乌肝毒性的临床案例报道日渐增多,其安全性备受关注。通过对生/制/发酵何首乌的化学成分、药理作用及肝毒性进行系统综述,为何首乌深度开发利用提供参考。
Polygoni multiflori radix is the root of Polygonum multiflorum Thunb.of Polygonaceae.There are many active chemical constituents in P.multiflorum,such as quinines,stilbenes,flavones,and phosphor lipids.P.multiflorum has many biological activities,includes anti-aging,hypolipidemic and anti-atherosclerosis effects.However,an increasing number of recently published studies have demonstrated the hepatoxicity of P.multiflorum,which draws attention of public.In this review,we provide a systematic comparison between P.multiflorum and related processed products in chemical constituents,pharmacology and hepatoxicity.It can be helpful for the further development and utilization of P.multiflorum.
作者
林艳
肖榕
李春
夏伯候
吴萍
林丽美
廖端芳
LIN Yan;XIAO Rong;LI Chun;XIA Bohou;WU Ping;LIN Limei;LIAO Duanfang(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208 Hunan,China;Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province,Changsha 410208 Hunan,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700 Beijing,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2018年第5期661-672,共12页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金青年基金项目(81503238)
国家中医药管理局中医药行业科研专项(201407003)
湖南省"十二五"重点学科药学学科资助项目(湘教发[2011]76号)
长沙市科技计划重点项目(k1406030-31)
湖南省教育厅一般项目(17C1213)
关键词
生何首乌
制何首乌
发酵何首乌
化学成分
药理作用
肝毒性
Raw Polygoni muhiflori radix
processed Polygoni muhiflori radix
fermented Polygoni multifloriradix
chemical constituents
pharmacology
hepatoxicity