分析阿奇霉素联合红霉素治疗小儿支原体肺炎的疗效

Analysis of Efficacy of Azithromycin Combined with Erythromycin in the Treatment of Mycoplasma Pneumonia in Children

目的探究阿奇霉素联合红霉素对小儿支原体肺炎的治疗效果,为临床推广提供重要的参考依据。方法方便选取该院2017年3月—2018年3月呼吸内科小儿支原体肺炎患者142例为研究对象。随机将患者分为对照组和观察组,每组71例。其中对照组小儿支原体肺炎患者通过红霉素进行治疗,观察组患者通过阿奇霉素与红霉素联合进行治疗,对两组患者的治疗效果进行对比分析。结果观察组进行阿奇霉素与红霉素联合治疗,可以有效提高治疗效果,观察组患者的痊愈率为92.96%,远远高于对照组的76.06%,两组差异有统计学意义(χ~2=11.785 1,P=0.005);观察组患者退热时间(1.86±0.71)d和止咳时间(2.45±1.46)d,而对照组患者退热时间(4.59±1.51)d和止咳时间(6.29±1.87)d,组间差异有统计学意义(χ~2=11.263 9,P=0.012)。另外观察组的不良反应发生率仅为26.76%,远低于对照组的64.79%,对照组和实验组的数据差异有统计学意义(χ~2=12.304 9,P=0.003)。结果通过对小儿支原体肺炎患者进行阿奇霉素联合红霉素治疗,不仅可以缩短痊愈的时间,而且可以减轻患者治疗过程中的痛苦,对小儿支原体肺炎的治疗具有重要意义。

Objective To investigate the effect of azithromycin combined with erythromycin in the treatment of mycoplasmapneumonia in children and provide an important reference for clinical promotion. Methods A total of 142 patients with mycoplasma pneumonia in the Department of Respiratory Medicine from March 2017 to March 2018 in the hospital were convenient selected as study subjects. Patients were randomly divided into control and observation groups, with 71 cases ineach group. In the control group, patients with mycoplasma pneumonia were treated with erythromycin, and patients in theobservation group were treated with azithromycin and erythromycin. The therapeutic effects of the two groups were compared. Results The combined treatment of azithromycin and erythromycin in the observation group could effectively improvethe therapeutic effect. The cure rate of the observation group was 92.96%, which was much higher than that of the controlgroup （76.06%）. the two groups had statistical significance （X^2=11.785 1, P=0.00 5）; In the observation group, the time offever （1.86±0.71）d and cough time （2.45±1.46）d were observed in the observation group, while the time of antipyretic treatment （4.59±1.51）d and cough retting （6.29±1.87）d in the control group. Differences between groups were statistically significant （X^2=11.263 9, P=0.012）. In addition, the incidence of adverse reactions in the observation group was only 26.76%,which was far lower than the 64.79% in the control group. The difference between the control group and the experimentalgroup was statistically significant （X^2=12.304 9, P=0.00 3）. Conclusion The treatment of azithromycin combined with erythromycin in patients with mycoplasma pneumonia in children can not only shorten the recovery time, but also reduce thepain during treatment. It is of great significance for the treatment of mycoplasma pneumonia in children.