3种方案治疗大面积脑梗死的临床应用研究

Clinical application research of three schemes in the treatment of massive hemispheric infarction

目的:探讨3种方案治疗急性大面积脑梗死的临床效果。方法:收治急性大面积脑梗死患者60例,随机分为3组,每组各20例。A组给予常规治疗,B组在常规治疗基础上给予针刺治疗,C组在常规治疗基础上给予针刺联合亚低温治疗,比较3组治疗前后NIHSS评分、神经功能缺损(ESS)、日常生活能力(ADL)评分、血清一氧化氮(NO)含量、C反应蛋白(CRP)含量。结果:治疗14 d、30 d,A组、B组NIHSS、ESS、ADL评分高于C组,差异有统计学意义(P<0.05)。A组NIHSS、ESS、ADL评分高于B组,差异有统计学意义(P<0.05)。治疗14 d,C组血清NO、CRP含量低于A组、B组,差异有统计学意义(P<0.05)。B组血清NO、CRP含量低于A组,差异有统计学意义(P<0.05)。结论:在常规治疗基础上给予针刺联合亚低温治疗急性大面积脑梗死可减轻梗死部位脑组织水肿,利于脑细胞及神经的功能恢复。

Objective：To explore the clinical effect of three schemes in the treatment of acute massive hemispheric infarction. Methods：60 cases of patients with acute massive hemispheric infarction were divided into three groups randomly.Group A was given routine treatment, Group B was treated with acupuncture on the basis of routine treatment,Group C was treated with acupuncture combined with mild hypothermia on the basis of routine treatment,the NIHSS score,nerve function defect （ESS）,daily living ability- （ADL） score,serum nitrogen oxide （NO） content and C reactive protein （CRP） content were compared among the three groups.Results：The scores of NIHSS, ESS and ADL in group A and group B were higher than those in C group after treatment for 14 d and 30 d,the difference was statistically significant （P 〈 0.05）.The scores of NIHSS,ESS and ADL in group A were higher than those in group B,and the difference was statistically significant （P 〈 0.05）.After treatment for 14 el,the levels of serum NO and CRP in group C were lower than those in group A and B,and the difference was statistically significant （P 〈 0.05）.The serum levels of NO and CRP in group B were lower than those in group A,the difference was statistically significant （P〈 0.05）.Conclusion： Acupuncture combined with mild hypothermia on the basis of routine treatment in the treatment of acute massive hemispheric infarction could reduce the cerebral edema in the infarct site and be beneficial to the functional recovery of brain cells and nerves.