阿司匹林联合氯吡格雷治疗急性脑梗死对患者认知功能的影响

Effect of Aspirin Combined with Clopidogrel on Cognitive Function in Patients with Acute Cerebral Infarction

目的观察阿司匹林联合氯吡格雷对急性脑梗死的治疗效果及对患者认知功能的影响。方法回顾性分析2016年2月-2017年8月在我院接受治疗的100例急性脑梗死患者的临床资料,根据其治疗方式分为对照组和观察组,每组50例。两组患者均给予常规治疗,对照组给予阿司匹林治疗,观察组给予阿司匹林联合氯吡格雷治疗。观察两组患者治疗前后MARAA、MARADP、NIHSS评分、认知功能和生活能力的差异。结果两组患者治疗前MARAA、MARADP水平无差异,治疗后,观察组MARAA、MARADP水平低于对照组;两组患者治疗前NIHSS评分无差异,治疗后,观察组NIHSS评分低于对照组(t=4.115,P<0.001);两组患者治疗前认知功能无差异,治疗后,观察组定向力、瞬时记忆等认知功能评分高于对照组;两组患者治疗前进食、洗澡、穿衣等日常生活能力评分无差异,治疗后,观察组日常生活能力评分高于对照组。结论阿司匹林联合氯吡格雷对急性脑梗死有较好的治疗效果,可明显改善患者的认知功能和生活能力,具有良好的应用价值。

Objective To observe the therapeutic effect of aspirin combined with clopidogrel against acute cerebral infarction and the effect on the cognitive function of patients. Methods The clinical data of 100 patients with acute cerebral infarction who received treatment in our hospital between February 2016 and August 2017 was retrospectively analyzed. These patients were divided into the control group and observation group according to their treatment. Both groups received routine treatment. The control group was given aspirin,while the observation group was treated with clopidogrel. The differences of MARAA,MARADP,NIHSS score,cognitive function and living ability were observed before and after treatment in the two groups. Results There was no difference in the levels of MARAA and MARADP,NIHSS scores,cognitive function scores,or in scores of daily living ability before treatment between the two groups. After treatment,the levels of MARAA and MARADP in the observation group were lower than those of the control group,the NIHSS score of the observation group was lower than that of the control group（ t = 4.115,P〈0. 001）,the cognitive function scores of the observation group,such as directional force and instantaneous memory,were higher than those in the control group,and the daily living ability score of the observation group was higher than that of the control group.Conclusion Aspirin combined with clopidogrel has a good therapeutic effect on acute cerebral infarction,which can significantly improve the cognitive function and life ability of patients,so this approach is worthy of application.