乳腺癌患者癌组织与血清HER-2的表达及临床价值

Clinical value of serum level and tissue expression of HER-2 in patients with breast cancer

目的:探讨乳腺癌患者血清HER-2与组织HER-2表达水平的相关性,以及血清HER-2的临床应用价值。方法:实验组选取临床诊断并经病检确诊的乳腺癌40例,乳腺良性肿瘤47例,对照组选取健康体检者44例,统一检测血清HER-2水平。结果:乳腺癌患者血清HER-2水平和阳性率(42.5%)高于乳腺良性肿瘤患者(17.02%)和健康体检者(15.91%);差异均有统计学意义(P<0.05)。血清HER-2在乳腺癌中具有较好的灵敏度(66.66%)和特异度(81.82%)。组织HER-2阳性和组织Ki-67阳性的乳腺癌患者血清HER-2的水平和阳性率高于组织HER-2阴性和组织Ki-67阴性的乳腺癌患者(P<0.05);组织分级越高的乳腺癌患者血清HER-2的阳性率越高(P<0.05)。结论:血清HER-2在乳腺癌患者中水平升高,具有较高的灵敏度和特异度,且与组织HER-2的表达具有相关性,对乳腺癌患者的诊断、预后有一定提示价值,有望成为乳腺癌患者癌组织HER-2检测的补充手段。

Objective ：To investigate the correlation between serum level and tissue expression of IIER-2 in patients with breast cancer as well as clinical value of serum IIER-2 in diagnosis of breast cancer. Methods：Observational group consisted of 40 malignant and 47 benign cases of clinically and patho- logically confirmed hreast lesions,and another 44 patients undergoing health examination were enrolled in the control group. All suhjeets were subjected to determination of serum level of I IER-2. Results：The serum I IER-2 level and its positive rate（42.5%） were significantly higher in breast cancer patients than those of benign breast lesions（17.02%） and healthy participants（15.91%）. The difference was statistically significant（P〈0.05）. Serum IIER-2 level had better sensitivity（ 66.66% ） and specificity（ 81.82% ） in breast cancer. Patients with positive tissue IIER-2 mad Ki-67 had higher serum IIER-2 lev- el than those with negative expression of IIER-2 and Ki-67（P〈0.05）. Positive rate of IIER-2 tended to be higher with increase of the histological grading in breast cancer patients（P〈0.05）. Conclusion：Serum IIER-2 level is significantly elevated in breast cancer patients, and has higher sensitivity and spe- cificity. Also, serum level of IIER-2 is correlated with tissue IIER-2 expression and valuable in diagnosis and predictor for prognosis of patients with hreast cancer,which may be expected to be the eomplementaryindicator for I IER-2 detection in breast cancer patients.