精神分裂症患者认知功能和血清GDNF水平的相关分析

Analysis on the cognitive dysfunction and serum glial cell derived neurotrophic factor level in patients with schizophrenia

目的:探讨精神分裂症(SZ)患者认知功能和血清胶质细胞源性神经营养因子(GDNF)水平的关系。方法:选取80名未服药的SZ患者,根据其是否首发分为首发组(38例)和复发组(42例),同时选取同期来本院进行体检的健康人为对照组(40例)。使用Stroop测验、言语流畅性测验(VFT)、数字划消测验(DCT)、连线测试(TMT)评估3组认知功能,采用ELISA法测定血清GDNF浓度,并分析认知功能和GDNF的关系。结果:正常组GDNF水平高于首发和复发组(F=15.368,P<0.01),后两者之间差异无统计学意义。首发组和复发组认知功能(除DCT)低于正常组,复发组的Stroop-色/词总数、VFT-动作测验和TMT-B认知低于首发组(P<0.05),并且这些测验和患者GDNF相关(P<0.05)。结论:SZ患者认知功能广泛受损,而复发患者受损更明显。GDNF可能参与了SZ认知功能损害的病理生理机制。

Objective ：To investigate the correlation between cognitive dysfunction and sermn glial cell derived neurotrophic factor（GDNF） level in pa- tients with schizophrenia（SZ）. Methods：Eighty drug-free SZ patients were included, and divided by the episode into first-episode group （n=38） and re- currence group（n=42）. Another 40 health suhjects were recruited as controls. The cognitive function was evaluated using Stroop Test, Verhal Fluency Test （ VFT）, Digital Cancellation Test （DCT）, Trail Making Test（TMT） in three groups, and GDNF level was measured hy the enzyme-linked immunosorhent assay（ELISA）. Then the relationship of GDNF level and cognitive dysfunction was analyzed. Results ：The serum GDNF level was higher in control group than in the first-episode and recurrence groups （F= 15.368, P〈 0.01 ） , yet the dift）rence was insignificant between the first-episode and the recurrence group （P〉0.05）. Patients in first-episode and recurrence groups were poorer in cognitive function （except DCT）, and those were poorer in the recurrence group than in the first-episode group concerning Stroop-colour word test ,TMT-B and VFT-action test results（P〈0.05） , and those tests were correlated with GDNF in SZ patients （ P〈0.05）. Conclusion ： Cognitive function is widely damaged in SZ patients, and the severity can be more serious in patients with relapsed SZ,suggesting that GDNF may be involved in the pathophysiology of cognitive impairment.