血必净注射液辅助西医治疗重症肺炎的有效性及安全性

Efficacy and safety of the Xuebijing injection and western medicine on severe pneumonia

目的:探讨血必净注射液辅助西医治疗重症肺炎的临床疗效及安全性。方法:选取2015年1月-2017年12月我院收治的300例重症肺炎患者作为研究对象,随机分为观察组和对照组,各150例。对照组给予抗感染、机械通气、祛痰等对症治疗,观察组在此基础上增加静脉滴注血必净注射液,连续治疗2周后,对比两组患者的临床有效性及安全性指标方面的差异。结果:观察组治疗后的白细胞计数、SaO2、PaCO2、PaO2/FiO2与对照组相比差异有显著性,且观察组患者的抗生素使用时间、机械通气时间及ICU住院天数明显缩短,治疗有效率显著提高(92.00%VS 80.67%,χ2=8.16,P <0.01),但肝肾功能及血小板计数等指标差异无统计学意义。结论:血必净注射液在重症肺炎的治疗中有积极的作用,能提高常规西药治疗的临床疗效。

Objective To explore the clinical efcacy and safety of the Xuebijing injection （血必净注射液 ） and western medicine on severe pneumonia. Methods： 300 cases were randomly divided into the observation group and the control group, 150 cases in each. The control group was given anti-infection, mechanical ventilation, expectorant and other symptomatic treatment. The observation group was given the Xuebijing injection more. After two weeks, the diferences of efciency and safety in two groups were compared. Results： The white blood cell count, SaO2, PaCO2, PaO2/FiO2 after treatment in the observation group were signifcantly diferent from those in the control group. The time of use of antibiotics, the time of mechanical ventilation and the days of ICU hospitalization in the observation group were signifcantly shorter, and the efective rate in the treatment group was signifcantly improved （92.00% VS 80.67%, χ2=8.16, P〈0.01）. There did not show signifcant diference in liver and kidney function and platelet count. Conclusion： The Xuebijing injection shows a positive efect, and can improve the clinical efcacy of conventional western medicine.