雷公藤多甙治疗48例糖尿病肾病患者的长期疗效观察

Long-term efficacy of GTW on 48 cases of diabetic nephropathy

目的:观察雷公藤多甙片对糖尿病肾病的长期临床治疗效果。方法:选取北京协和医院中医科2015年1月-2017年1月门诊的糖尿病肾病患者48例。所有患者予控制血糖、血压、血脂等西医基础治疗。采用自身前后对照研究,在治疗前、治疗3个月、治疗6个月、治疗12个月的时候,观察患者24h尿蛋白定量指标变化,并观察血清白蛋白、血肌酐的变化,同时监测血常规及肝功能。结果:经治疗3个月、6个月、12个月均提示24h尿蛋白定量较前下降,治疗12个月终点血清白蛋白上升,治疗前后差异具有统计学意义(P <0.05),血肌酐治疗前后差异无统计学意义(P> 0.05)。结论:雷公藤多甙长期用于治疗糖尿病肾病患者可以减少蛋白尿,提升血清白蛋白,保护肾功能,且安全性可靠。

Objective To observe the long-term clinical efect of GTW on diabetic nephropathy. Methods： 48 patients were given control blood sugar, blood pressure, blood lipids. The changes of 24-hour urinary protein quantification, serum albumin and serum creatinine were observed by self-contrast studies before treatment, at 3 months, 6 months and 12 months. Blood routine and liver function were monitored. Results： After 3 months, 6 months and 12 months, the 24-hour urinary protein quantification was lower than before treatment, and the serum albumin increased after 12 months, with statistically signifcant diferences （P〈0.05）. The diference of serum creatinine before and after treatment did not show statistically signifcant （P〉0.05）. Conclusion： GTW can reduce proteinuria, increase serum albumin, protect renal function, and provide reliable safety.