FGFR抑制剂的研究进展

Research progress of FGFR inhibitors

成纤维细胞生长因子受体(FGFRs)信号通路的异常激活与肿瘤、骨骼发育异常等多种疾病的发生、发展具有密切关系。靶向FGFRs的抑制剂具有治疗相关疾病的潜力,越来越多的研究机构和制药公司将其作为具有前景的治疗靶标,FGFRs抑制剂已成为靶向药物研究的热点之一。对近年来FGFRs抑制剂药物的相关研究进展进行了综述。

Abnormal activation of the FGFRs signaling pathway is closely related to the occurrence and development of various diseases, such as tumor and skeletal dysplasia. The inhibitors targeting FGFRs have the potential to treat related diseases. More and more research institutions and pharmaceutical companies have shown increasing interest in using FGFRs as a promising therapeutic target. FGFRs inhibitors have become one of the research hotspots in the fields of targeted drugs. In this article, recent advances in FGFRs inhibitors are reviewed.