上肢骨折手术患者采用氟比洛芬酯超前镇痛效果分析

Analysis of the Effect of Preemptive Analgesia with Flurbiprofen Axetil in Patients with Upper Limb Fractures

目的探讨上肢骨折手术患者采用氟比洛芬酯超前镇痛的术后镇痛效果。方法选取2017年5月—2018年3月于该院接受上肢骨折内固定手术患者120例,随机分为对照组和观察组,各60例。术前对照组行口服塞来昔布镇痛方案,观察组行静脉注射氟比洛芬酯超前镇痛方案。术后比较两组患者镇痛效果、睡眠质量以及不良反应的发生情况。结果研究发现观察组与对照组VAS得分相比明显得分较低,对照组t1为(2.13±0.68)分,t2为(3.34±0.42)分;观察组t1为(1.40±0.21)分,t2为(1.73±0.23)分,组间差异有统计学意义(t=8.093,P<0.01;t=7.132,P<0.01),且术后观察组睡眠质量较对照组要好(对照组AB级比例为81.70%,观察组AB级比例为95.00%),差异有统计学意义(P<0.05),但两组患者的不良反应发生率(对照组为6.67%,观察组为5.00%),差异无统计学意义(χ~2=0.545 3,P>0.05)。结论上肢骨折手术患者术前采用氟比洛芬酯超前镇痛,可有效减轻患者术后疼痛,提高睡眠质量,药物作用安全,具有重要的临床意义。

Objective To investigate the postoperative analgesic effect of flurbiprofen axetil in patients undergoing upper limb fracture surgery. Methods A total of 120 patients undergoing internal fixation of upper limb fractures from May 2017 to March 2018 were convenient selected and randomly divided into a control group and an observation group with 60 patients in each group. The preoperative control group received an oral celecoxib analgesic regimen. The observation group received an intravenous analgesic regimen of flurbiprofen axetil. The postoperative analgesic effect, sleep quality, and incidence of adverse reactions were compared between the two groups. Results The study found that the VAS scores of the observation group and the control group were significantly lower than the control group ,control group tl is（2.13±0.68）points, t2 is （3.34±0.42）points; observation group tl is （1.40±0.21）points, t2 is （1.73±0.23）points. There was a difference between groups, with statistical significance（t=8.093, P〈0.01; t=7.132, P〈0.01）, and postoperative observation group sleep quality was better than control group （control group AB grade ratio 81.70%, observation group AB proportion was 95.00%,（P〈0.05）, but there was no significant difference in the incidence of adverse reactions between the two groups control group （6.67%） vs observation group（5.00%）,the different was statistically significant（χ2=0.545 3, P〉0.05）. Conclusion Preoperative analgesia with flurbiprofen axetil in patients with upper limb fractures can effectively reduce postoperative pain, improve sleep quality, and have a safe drug effect. It has important clinical significance.