摘要
目的探讨Y-box结合蛋白-1(YB-1)与增殖细胞核抗原(PCNA)在胃癌组织中的表达及其与临床病理特征的相关性。方法采用免疫组化法检测并比较116例胃癌组织(实验组)以及20例癌旁组织(对照组)中YB-1和PCNA的表达,并分析YB-1和PCNA表达与其临床病理特征的相关性。结果实验组YB-1表达阳性81例(69. 83%),PCNA表达阳性72例(62. 07%),另外对照组中YB-1表达阳性4例(20. 00%),PCNA表达阳性3例(15. 00%),2组间YB-1、PCNA的阳性表达差异均有统计学意义(P <0. 01)。胃癌组织中YB-1和PCNA阳性表达与患者年龄、性别无关(P>0. 05),与AJCC分期、分化程度、淋巴结转移及肌层浸润深度有相关性(P <0. 01)。经Spearman相关分析结果显示:YB-1表达与PCNA表达呈正相关性(γ=0. 478,P <0. 05)。结论 YB-1和PCNA均可作为胃癌的肿瘤标志物,联合检测可为胃癌的早期诊断、病理分级提供重要参考依据,也为临床抗肿瘤治疗提供新方向。
Objective To investigate the expression of Y-box binding protein-1 (YB-1) and proliferating cell nuclear antigen (PCNA) in gastric carcinoma and its correlation with clinicopathological features. Methods Immunohistochemistry was used to detect the expression of YB-1 and PCNA in 116 cases of gastric cancer (experimental group) and 20 cases of normal tissues (control group),and correlation analysis of YB-1 and PCNA expression with clinicopathological features. Results There were 81 cases (69.83%) of positive expression of YB-1 in the experimental group and 72 cases (62.07%) in PCNA expression,4 cases (20.00%) and 3 cases (15.00%) in the control group,the positive expression of YB-1 and PCNA in the 2 groups was statistically significant ( P〈0.01).The positive expression of YB-1 and PCNA in gastric carcinoma was not correlated with age and sex ( P〉0.05),which was correlated with AJCC stage,differentiation degree,lymph node metastasis and depth of myometrial invasion ( P〈0.01).The results of Spearman correlation analysis showed that YB-1 expression was positively correlated with PCNA expression ( γ =0.478, P〈0.05). Conclusion YB-1 and PCNA can be used as tumor markers of gastric cancer.Combined detection can provide an important reference for the early diagnosis,pathological grade and prognosis of gastric cancer,and also provide a new direction for clinical anti-tumor therapy.
作者
孙晓
SUN Xiao.(Affiliated Hospital of Zhengzhou University,Nanyang Central Hospital,Nanyang,47300)
出处
《实用癌症杂志》
2018年第10期1575-1578,共4页
The Practical Journal of Cancer