天晴甘美联合熊去氧胆酸治疗原发性胆汁性肝硬化疗效及对肝功酶谱的影响

Efficacy of magnesium isoglycyrrhizinate injection combined with ursodeoxycholic acid on primary biliary cirrhosis and its effects on liver function zymogram

目的:观察天晴甘美联合熊去氧胆酸治疗原发性胆汁性肝硬化的临床疗效。方法:将本院消化内科门诊收治的140例患者随机分为对照组和实验组,每组各70例,对照组予以熊去氧胆酸治疗,实验组在对照组的基础上加上天晴甘美,1个疗程为4周,两组均进行1个疗程的治疗,疗程结束后,观察比较两组患者的总有效率、肝纤维化指标、肝功酶谱。结果:疗程结束后,实验组的总有效率为85. 71%,高于对照组的62. 29%,差异有统计学意义(P <0. 05);经治疗后,两组的肝纤维化指标均下降,实验组与对照组比较,差异有统计学意义(P <0. 05);疗程结束后,两组的肝功酶谱均有改善,且实验组与对照组比较,差异有统计学意义(P <0. 05)。结论:天晴甘美联合熊去氧胆酸治疗原发性胆汁性肝硬化的疗效确切,可以提高有效率,降低各项肝纤维化指标,改善肝功酶谱。

Objective ： To observe the clinical efficacy of magnesium isoglycyrrhizinate injection combined with ursodeoxy eholie acid in the treatment of primary biliary cirrhosis. Methods ： 140 patients admitted to the department of gastroenterology of our hospital were randomly divided into control group and experimental group with 70 cases in each group. Conlrol group was given ursodeoxycholic acid, and experimental group was given magnesium isoglycyrrhizinale injection on the basis of control group, and the two groups were treated for 1 course as 4 weeks for every course. At the end of treatment, the total effective rate, liver fibrosis indexes and liver function zymogranl were observed and compared between the two groups. Results： After treatment, the total effective rate in experimental group was higher than that in control group 985.71% vs 62.29% ） （P 〈 0.05）. After treatment, the liver fibrosis indexes in the two groups were decreased, and the difference between the two groups was statistically significant （P 〈 0.05 ）. At the end of treatment, the liver function zymogranl was improved in the two groups, and the difference between experimental group and control group was statistically significant （P 〈 0.05 ）. Conclusions： Magnesium isoglyeyrrhizinate injection combined with ursodeoxyeholie acid can have definite effects in the treatment of primary biliary cirrhosis.