他汀类药物减轻肝脏缺血再灌注损伤的研究进展

Research advances of statins on liver ischemic reperfusion injury

缺血再灌注损伤(IRI)是肝切除和肝移植不可避免的损伤过程,也是肝移植主要的损伤危险因素之一,影响肝移植受者术后近、远期疗效。他汀类药物能上调内皮细胞Kruppel样因子2表达,产生抗炎、抗血栓形成、抗氧化应激、抗凋亡等保护作用。本文主要综述他汀类药物减轻肝脏IRI的研究进展。

Ischemic reperfusion injury is almost unavoidable in liver resection surgery and liver transplantation, which is also one of the major risk factors of liver transplantation and affects the short- term and long- term outcome of liver transplantation recipients. Previous study found that Kruppel- like factor 2 induced by stains play an protective role in the regulation of endothelial function, such as anti- inflammation, anti- thrombosis, anti- oxidant stress, anti- apoptosis, and so on. This review summarizes the current understanding of statins on liver ischemic reperfusion injury. 【Key words】