循环肿瘤DNA在结直肠癌临床诊疗中的应用价值研究

Study on the Application Value of Circulating Tumor DNA in Clinical Diagnosis and Treatment of Colorectal Cancer

结直肠癌(CRC)属常见消化道恶性肿瘤之一,临床早期诊断较为困难,多数患者确诊时多已进展至中晚期,不利于治疗的充分展开,预后较差。ctDNA检测是一种新兴技术,能够克服传统肿瘤组织活检的缺点,具有操作便捷、高重复性、能够克服肿瘤的异质性等优点,患者接受度高,在早期诊断、判断疗效、指导靶向用药、评估预后等方面均具有显著应用价值,现综述如下。

Department of Oncology, Liyang People＇s Hospital, Changzhou, Jiangsu Province, 213300 China [Abstract] Colorectal cancer （CRC） is one of the most common malignant gastrointestinal cancers. Early diagnosis is difficult. Most patients have advanced to the middle and late stages when diagnosed, which is not conducive to the full development of the treatment and the prognosis is poor. ctDNA detection is an emerging technology that can overcome the shortcomings of traditional tumor biopsy, has the advantages of convenient operation, high repeatability, ability to overcome the heterogeneity of the tumor, etc., and has high patient acceptance, which has significant application value in early diagnosis, judgment of curative effect, and guidance use of drugs, assessment of prognosis and other aspects, being summarized below.